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|Title:||MspA1 polymorphism of the CYP17 gene in breast cysts|
|Authors:||Tote Franco Pinotti, Solange Cristina [UNIFESP]|
Cotrim Guerreiro da Silva, Ismael Dale [UNIFESP]
Carvalho, Cristina Valeta [UNIFESP]
Pinto Nazario, Afonso Celso [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
|Citation:||Gynecological Endocrinology. New York: Informa Healthcare, v. 28, n. 6, p. 443-446, 2012.|
|Abstract:||Objective: To study the prevalence of breast cysts in several age groups of the general female population and their association with the MspAI polymorphism of the gene CYP17. Results: in 204 ultrasound tests, cysts were present in 22% of the studied population. the epidemiological-clinical profile of these women was Caucasian, aged 41-50 years, regular menstrual cycles, multiparous and complaining of mastalgia. the genetic distribution of polymorphisms of the gene displayed Hardy-Weinberg equilibrium and the wild homozygous phenotype was observed in 36.4% of the case group and in 37.6% of the control groups; the heterozygous phenotype was observed in 50% of the study group and 46.3% of control group and a mutated homozygous phenotype was seen in 13.6% of the study group and 16.1% of the controls. There was no statistically significant difference between the groups (p = 0.92). Conclusion: the prevalence and most of the epidemiological profile of breast cysts were in agreement with the literature. There was no statistically significant difference among the genotypic groups (wild homozygous, heterozygous and mutated homozygous), despite a slightly increased frequency of the mutated genotype in the control group. This difference indicates a trend of the MspAI polymorphism of the gene CYP17 to act as a protective factor against the development of breast cysts.|
|Appears in Collections:||Artigo|
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