Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/34984
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dc.contributor.authorGigek, Carolina Oliveira [UNIFESP]
dc.contributor.authorChen, Elizabeth Suchi [UNIFESP]
dc.contributor.authorCalcagno, Danielle Queiroz [UNIFESP]
dc.contributor.authorWisnieski, Fernanda [UNIFESP]
dc.contributor.authorBurbano, Rommel Rodriguez
dc.contributor.authorCardoso Smith, Marilia Arruda [UNIFESP]
dc.date.accessioned2016-01-24T14:27:21Z-
dc.date.available2016-01-24T14:27:21Z-
dc.date.issued2012-06-01
dc.identifierhttp://dx.doi.org/10.2217/EPI.12.22
dc.identifier.citationEpigenomics. London: Future Medicine Ltd, v. 4, n. 3, p. 279-294, 2012.
dc.identifier.issn1750-1911
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34984-
dc.description.abstractCancer is considered one of the major health issues worldwide, and gastric cancer accounted for 8% of total cases and 10% of total deaths in 2008. Gastric cancer is considered an age-related disease, and the total number of newly diagnosed cases has been increasing as a result of the higher life expectancy. Therefore, the basic mechanisms underlying gastric tumorigenesis is worth investigation. This review provides an overview of the epigenetic mechanisms, such as DNA methylation, histone modifications, chromatin remodeling complex and miRNA, involved in gastric cancer. As the studies in gastric cancer continue, the mapping of an epigenome code is not far for this disease. in conclusion, an epigenetic therapy might appear in the not too distant future.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent279-294
dc.language.isoeng
dc.publisherFuture Medicine Ltd
dc.relation.ispartofEpigenomics
dc.rightsAcesso restrito
dc.subjectchromatin remodeling complexen
dc.subjectDNA methylationen
dc.subjectepigeneticsen
dc.subjectgastric canceren
dc.subjecthistone acetylationen
dc.subjecthistone methylationen
dc.subjecthypermethylationen
dc.subjectmiRNAen
dc.subjectphosphorylationen
dc.titleEpigenetic mechanisms in gastric canceren
dc.typeResenha
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFed Univ Para
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Genet, Dept Morfol & Genet, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.affiliationFed Univ Para, Lab Citogenet Humana, Inst Ciencias Biol, BR-66059 Belem, PA, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Genet, Dept Morfol & Genet, Escola Paulista Med, BR-04023900 São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2009/07145-9
dc.identifier.doi10.2217/EPI.12.22
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000306530200007
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