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Title: Epigenetic mechanisms in gastric cancer
Authors: Gigek, Carolina Oliveira [UNIFESP]
Chen, Elizabeth Suchi [UNIFESP]
Calcagno, Danielle Queiroz [UNIFESP]
Wisnieski, Fernanda [UNIFESP]
Burbano, Rommel Rodriguez
Cardoso Smith, Marilia Arruda [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Fed Univ Para
Keywords: chromatin remodeling complex
DNA methylation
gastric cancer
histone acetylation
histone methylation
Issue Date: 1-Jun-2012
Publisher: Future Medicine Ltd
Citation: Epigenomics. London: Future Medicine Ltd, v. 4, n. 3, p. 279-294, 2012.
Abstract: Cancer is considered one of the major health issues worldwide, and gastric cancer accounted for 8% of total cases and 10% of total deaths in 2008. Gastric cancer is considered an age-related disease, and the total number of newly diagnosed cases has been increasing as a result of the higher life expectancy. Therefore, the basic mechanisms underlying gastric tumorigenesis is worth investigation. This review provides an overview of the epigenetic mechanisms, such as DNA methylation, histone modifications, chromatin remodeling complex and miRNA, involved in gastric cancer. As the studies in gastric cancer continue, the mapping of an epigenome code is not far for this disease. in conclusion, an epigenetic therapy might appear in the not too distant future.
ISSN: 1750-1911
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Appears in Collections:Em verificação - Geral

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