Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/34936
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dc.contributor.authorDutra, Livia Almeida [UNIFESP]
dc.contributor.authorGoncalves, Celio Roberto
dc.contributor.authorBraga-Neto, Pedro [UNIFESP]
dc.contributor.authorPedroso, Jose Luiz [UNIFESP]
dc.contributor.authorGabbai, Alberto Alain [UNIFESP]
dc.contributor.authorBarsottini, Orlando Graziani Povoas [UNIFESP]
dc.contributor.authorSilva de Souza, Alexandre Wagner [UNIFESP]
dc.date.accessioned2016-01-24T14:27:18Z
dc.date.available2016-01-24T14:27:18Z
dc.date.issued2012-06-01
dc.identifierhttp://dx.doi.org/10.1007/s00415-011-6319-z
dc.identifier.citationJournal of Neurology. Heidelberg: Springer Heidelberg, v. 259, n. 6, p. 1159-1165, 2012.
dc.identifier.issn0340-5354
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34936
dc.description.abstractType and frequency of systemic and neurologic manifestations of Beh double dagger et's disease (BD) vary with ethnicity. in Brazil, BD occurs as sporadic cases. We describe clinical and radiological features of 36 Brazilian patients of mixed ethnicity with neuro-Beh double dagger et's disease (NBD). Medical records of 178 BD patients were reviewed and 36 (20%) NBD patients were identified. Twenty-one NBD patients (58.3%) were female and 27 (75%) presented with parenchymal manifestations. Brainstem involvement was the most common neurologic syndrome (41.7%). Seizures (27.8%), isolated aseptic meningitis (16.7%), optic neuropathy (ON) (16.7%), cerebral venous thrombosis (CVT) (8.3%), peripheral neuropathy (2.8%), and spinal cord involvement (5.6%) were other neurologic manifestations observed among Brazilian NBD patients. Eighteen (50%) had at least one relapse, and isolated aseptic meningitis was the most common relapsing manifestation. No significant differences concerning the number of relapses between parenchymal and non-parenchymal groups were found. A multivariate model including disease duration, cell count in spinal fluid, cyclosporine use, immunosuppressive use at disease onset, age at NBD onset, and ON did not reveal any significant associations with NBD relapse. There was a low frequency of CVT and an unexpected higher number of isolated aseptic meningitis. Brazilian NBD patients present more parenchymal and atypical manifestations, and relapse more often than NBD patients from other populations.en
dc.format.extent1159-1165
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Neurology
dc.rightsAcesso restrito
dc.subjectBehcet's syndromeen
dc.subjectNeuro-Behcet's diseaseen
dc.subjectEpilepsyen
dc.subjectPeripheral neuropathyen
dc.subjectStrokeen
dc.subjectCerebral venous thrombosisen
dc.subjectOptic neuropathyen
dc.subjectDemyelinating syndromeen
dc.titleAtypical manifestations in Brazilian patients with neuro-Behcet's diseaseen
dc.typeArtigo
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Israelita Albert Einstein
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniversidade Federal de São Paulo, Gen Neurol Div, Dept Neurol & Neurosurg, BR-04039002 São Paulo, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Inst Israelita Ensino & Pesquisa Albert Einstein, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Div Rheumatol, Dept Med, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Rheumatol, Dept Med, BR-04039002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Gen Neurol Div, Dept Neurol & Neurosurg, BR-04039002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Rheumatol, Dept Med, BR-04039002 São Paulo, Brazil
dc.identifier.doi10.1007/s00415-011-6319-z
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000304859300021
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