Please use this identifier to cite or link to this item:
|Title:||HIV-1 Proviral DNA Loads (as Determined by Quantitative PCR) in Patients Subjected to Structured Treatment Interruption after Antiretroviral Therapy Failure|
|Authors:||Komninakis, Shirley V. [UNIFESP]|
Santos, Domingos E. M. [UNIFESP]
Oliveros, Marcia P. R.
Diaz, Ricardo S. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
|Publisher:||Amer Soc Microbiology|
|Citation:||Journal of Clinical Microbiology. Washington: Amer Soc Microbiology, v. 50, n. 6, p. 2132-2133, 2012.|
|Abstract:||The impact of Structured Treatment Interruption (STI) in peripheral blood mononuclear cell (PBMC) proviral reservoirs in 41 highly active antiretroviral therapy (HAART)-treated viremic individuals at baseline and 12 weeks after STI was determined using quantitative PCR (qPCR). Viral load increased 0.7 log(10) and CD4 decreased 97.5 cells/mm(3) after 12 weeks. A total of 28 of the 41 individuals showed an increased proviral load, 19 with a statistically significant increase above 10%. An increase in active viral replication is an important factor in the replenishment of the proviral reservoir even for short time periods.|
|Appears in Collections:||Artigo|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.