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http://repositorio.unifesp.br/handle/11600/34919| Title: | HIV-1 Proviral DNA Loads (as Determined by Quantitative PCR) in Patients Subjected to Structured Treatment Interruption after Antiretroviral Therapy Failure |
| Authors: | Komninakis, Shirley V. [UNIFESP] Santos, Domingos E. M. [UNIFESP] Santos, Carlos Oliveros, Marcia P. R. Sanabani, Sabri Diaz, Ricardo S. [UNIFESP] Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
| Issue Date: | 1-Jun-2012 |
| Publisher: | Amer Soc Microbiology |
| Citation: | Journal of Clinical Microbiology. Washington: Amer Soc Microbiology, v. 50, n. 6, p. 2132-2133, 2012. |
| Abstract: | The impact of Structured Treatment Interruption (STI) in peripheral blood mononuclear cell (PBMC) proviral reservoirs in 41 highly active antiretroviral therapy (HAART)-treated viremic individuals at baseline and 12 weeks after STI was determined using quantitative PCR (qPCR). Viral load increased 0.7 log(10) and CD4 decreased 97.5 cells/mm(3) after 12 weeks. A total of 28 of the 41 individuals showed an increased proviral load, 19 with a statistically significant increase above 10%. An increase in active viral replication is an important factor in the replenishment of the proviral reservoir even for short time periods. |
| URI: | http://repositorio.unifesp.br/handle/11600/34919 |
| ISSN: | 0095-1137 |
| Other Identifiers: | http://dx.doi.org/10.1128/JCM.00393-12 |
| Appears in Collections: | Artigo |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| WOS000305119000059.pdf | 140.71 kB | Adobe PDF | View/Open |
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