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Title: Acute and short-term effect of an extra dose of formoterol in COPD patients
Authors: Studart, Fernando Sérgio [UNIFESP]
Izbicki, Meyer [UNIFESP]
Nery, Luiz Eduardo [UNIFESP]
Oliveira, Luis Vicente Franco
Donner, Claudio F.
Jardim, José Roberto [UNIFESP]
Nascimento, Oliver Augusto [UNIFESP]
Mondo Med Multidisciplinary & Rehabil Outpatient
Universidade Federal de São Paulo (UNIFESP)
Nove Julho Univ
Keywords: COPD
Issue Date: 1-Jun-2012
Publisher: W B Saunders Co Ltd
Citation: Respiratory Medicine. London: W B Saunders Co Ltd, v. 106, n. 6, p. 853-860, 2012.
Abstract: Rationale: Formoterol action may decrease progressively after its inhalation. It is unknown if this decrease of bronchodilation following formoterol use could be associated with worsening hyperinflation.Objectives: To investigate whether the use of an extra daily dose of formoterol could promote a greater reduction in lung hyperinflation and a greater improvement in inspiratory capacity (IC) compared to usual doses.Methods: 56 hyperinflated COPD patients were divided into two groups: F2 and F3. Basal evaluation was carried out after 5 days of formoterol washout. in order to evaluate the acute effect, spirometry and body plethysmography were performed 8 h after the first formoterol dose in both groups and repeated 1 h after an additional formoterol dose (F3) or placebo (F2). the short-term effect was evaluated by measuring the resting lung function after a 14-day period of formoterol t.i.d. (F3) or formoterol b.i.d. + placebo (F2).Measurements and main results: A second formoterol dose inhaled 8 h after the previous dose promoted additional improvements in lung function, as demonstrated by higher IC (118 +/- 140 mL, p < 0.001) and tower functional residual capacity (FRC) (-383 +/- 367 mL, p <0.001). On day 15, the mean differences from baseline regarding all lung function variables were similar between the groups.Conclusion: An extra daily dose of formoterol inhaled 8 h after a previous dose could result in an acute additional peak of bronchodilation. However, short-term formoterol t.i.d. showed no advantages over formoterol b.i.d. concerning reduction of hyperinflation in resting lung function. (C) 2012 Elsevier B.V. All rights reserved.
ISSN: 0954-6111
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