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Title: Low-level laser therapy improves repair following complete resection of the sciatic nerve in rats
Authors: Medalha, Carla Christina [UNIFESP]
Di Gangi, Giuliana Castro [UNIFESP]
Barbosa, Caroline Bublitz [UNIFESP]
Fernandes, Marcela [UNIFESP]
Aguiar, Odair [UNIFESP]
Faloppa, Flavio [UNIFESP]
Leite, Vilnei Mattioli [UNIFESP]
Muniz Renno, Ana Claudia [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: Laser therapy
Nerve regeneration
Sciatic nerve
Issue Date: 1-May-2012
Publisher: Springer
Citation: Lasers in Medical Science. London: Springer London Ltd, v. 27, n. 3, p. 629-635, 2012.
Abstract: The aim of this study is to analyze the effects of low-level laser therapy (LLLT) on the regeneration of the sciatic nerve in rats following a complete nerve resection. Male Wistar rats were divided into a control injury group, injury groups irradiated with a 660-nm laser at 10 or 50 J/cm(2), and injury groups irradiated with an 808-nm laser at 10 or 50 J/cm(2). Treatment began 24 h following nerve resection and continued for 15 days. Using the sciatic functional index (SFI), we show that the injured animals treated with 660 nm at 10 and 50 J/cm(2) had better SFI values compared with the control injury and the 808-nm groups. Animals irradiated with the 808-nm laser at 50 J/cm(2) show higher values for fiber density than do control animals. in addition, axon and fiber diameters were larger in animals irradiated with 660 nm at 50 J/cm(2) compared to the control group. These findings indicate that 660-nm LLLT is able to provide functional gait recovery and leads to increases in fiber diameter following sciatic nerve resection.
ISSN: 0268-8921
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