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Title: Gut-central nervous system axis is a target for nutritional therapies
Authors: Pimentel, Gustavo D. [UNIFESP]
Micheletti, Thayana O.
Pace, Fernanda
Rosa, Jose C. [UNIFESP]
Santos, Ronaldo V. T. [UNIFESP]
Lira, Fabio Santos de [UNIFESP]
Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ So Santa Catarina UNESC
Jose Caetano de Lima
Keywords: Gut
Central nervous system
Inflammatory disease
Issue Date: 10-Apr-2012
Publisher: Biomed Central Ltd
Citation: Nutrition Journal. London: Biomed Central Ltd, v. 11, 9 p., 2012.
Abstract: Historically, in the 1950s, the chemist Linus Pauling established a relationship between decreased longevity and obesity. At this time, with the advent of studies involving the mechanisms that modulate appetite control, some researchers observed that the hypothalamus is the appetite centre and that peripheral tissues have important roles in the modulation of gut inflammatory processes and levels of hormones that control food intake. Likewise, the advances of physiological and molecular mechanisms for patients with obesity, type 2 diabetes mellitus, inflammatory bowel diseases, bariatric surgery and anorexia-associated diseases has been greatly appreciated by nutritionists. Therefore, this review highlights the relationship between the gut-central nervous system axis and targets for nutritional therapies.
ISSN: 1475-2891
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Appears in Collections:Artigo

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