Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/34794
Title: Clinical implication of 14-3-3 epsilon expression in gastric cancer
Authors: Leal, Mariana Ferreira [UNIFESP]
Calcagno, Danielle Queiroz [UNIFESP]
Demachki, Samia
Assumpcao, Paulo Pimentel
Chammas, Roger
Burbano, Rommel Rodriguez
Smith, Marilia de Arruda Cardoso [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Fed Univ Para
Universidade de São Paulo (USP)
Keywords: Gastric cancer
14-3-3 epsilon
YWHAE
Gene expression
Protein expression
Issue Date: 7-Apr-2012
Publisher: Baishideng Publishing Group Inc
Citation: World Journal of Gastroenterology. Pleasanton: Baishideng Publishing Group Inc, v. 18, n. 13, p. 1531-1537, 2012.
Abstract: AIM: To evaluate for the first time the protein and mRNA expression of 14-3-3 epsilon in gastric carcinogenesis.METHODS: 14-3-3 epsilon protein expression was determined by western blotting, and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue samples.RESULTS: Authors observed a significant reduction of 14-3-3 epsilon protein expression in gastric cancer (GC) samples compared to their matched non-neoplastic tissue, Reduced levels of 14-3-3 epsilon were also associated with diffuse-type GC and early-onset of this pathology. Our data suggest that reduced 14-3-3 epsilon may have a role in gastric carcinogenesis process.CONCLUSION: Our results reveal that the reduced 14-3-3 epsilon expression in GC and investigation of 14-3-3 epsilon interaction partners may help to elucidate the carcinogenesis process. (C) 2012 Baishideng. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/34794
ISSN: 1007-9327
Other Identifiers: http://dx.doi.org/10.3748/wjg.v18.i13.1531
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