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Title: Reinfarction after percutaneous coronary intervention or medical management using the universal definition in patients with total occlusion after myocardial infarction: Results from long-term follow-up of the Occluded Artery Trial (OAT) cohort
Authors: White, Harvey D.
Reynolds, Harmony R.
Carvalho, Antonio C. [UNIFESP]
Pearte, Camille A.
Liu, Li
Martin, C. Edwin
Knatterud, Genell L.
Dzavik, Vladimir
Kruk, Mariusz
Steg, Philippe Gabriel
Cantor, Warren J.
Menon, Venu
Lamas, Gervasio A.
Hochman, Judith S.
Auckland City Hosp
Universidade Federal de São Paulo (UNIFESP)
Clin Trials & Surveys Corp
York Hosp
Univ Hlth Network
Maryland Med Res Inst
Natl Inst Cardiol
Hop Bichat Claude Bernard
Univ Paris Diderot
Southlake Reg Hlth Ctr
Cleveland Clin
Columbia Univ
Issue Date: 1-Apr-2012
Publisher: Elsevier B.V.
Citation: American Heart Journal. New York: Mosby-Elsevier, v. 163, n. 4, p. 563-571, 2012.
Abstract: Background the OAT study randomized 2,201 patients with a totally occluded infarct-related artery on days 3 to 28 (>24 hours) after myocardial infarction (MI) to percutaneous coronary intervention (PCI) or medical treatment (MED). There was no difference in the primary end point of death, reinfarction, or heart failure at 2.9 or 6-year mean follow-up. However, in patients randomized to PCI, there was a trend toward a higher rate of reinfarction.Methods We analyzed the characteristics and types of reinfarction according to the universal definition. Independent predictors of reinfarction were determined using Cox proportional hazard models with follow-up up to 9 years.Results There were 169 reinfarctions: 9.4% PCI vs 8.0% MED, hazard ratio 1.31, 95% CI 0.97-1.77, P = .08. Spontaneous reinfarction (type 1) occurred with similar frequency in the groups: 4.9% PCI vs 6.7% MED, hazard ratio 0.78, 95% CI 0.53-1.15, P = .21. Rates of type 2 (secondary) and 3 (sudden death) MI were similar in both groups. There was an increase in type 4a reinfarctions (related to protocol or other PCI) (0.8% PCI vs 0.1% MED, P = .01) and type 4b reinfarctions (stent thrombosis) (2.7% PCI vs 0.6% MED, P < .001). Multivariate predictors of reinfarction were history of PCI before study entry (P = .001), diabetes (P = .005), and absence of new Q waves with the index infarction (P = .01).Conclusions There was a trend for reinfarctions to be more frequent with PCI. Opening an occluded infarct-related artery in stable patients with late post-MI may expose them to a risk of subsequent reinfarction related to reocclusion and stent thrombosis. (Am Heart J 2012; 163:563-71.)
ISSN: 0002-8703
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