Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/34716
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dc.contributor.authorPolonelli, Luciano
dc.contributor.authorCiociola, Tecla
dc.contributor.authorMagliani, Walter
dc.contributor.authorZanello, Pier Paolo
dc.contributor.authorD'Adda, Tiziana
dc.contributor.authorGalati, Serena
dc.contributor.authorDe Bernardis, Flavia
dc.contributor.authorArancia, Silvia
dc.contributor.authorGabrielli, Elena
dc.contributor.authorPericolini, Eva
dc.contributor.authorVecchiarelli, Anna
dc.contributor.authorArruda, Denise C. [UNIFESP]
dc.contributor.authorPinto, Marcia R.
dc.contributor.authorTravassos, Luiz Rodolpho [UNIFESP]
dc.contributor.authorPertinhez, Thelma A.
dc.contributor.authorSpisni, Alberto
dc.contributor.authorConti, Stefania
dc.date.accessioned2016-01-24T14:26:59Z
dc.date.available2016-01-24T14:26:59Z
dc.date.issued2012-03-21
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0034105
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 7, n. 3, 10 p., 2012.
dc.identifier.issn1932-6203
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34716
dc.description.abstractSynthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro. An Fc-peptide, included in all human IgGs, displayed a therapeutic effect against experimental mucosal and systemic candidiasis in mouse models. It is intriguing to hypothesize that some Fc-peptides may influence the antifungal immune response and constitute the basis for devising new antifungal agents.en
dc.description.sponsorshipItalian Ministry of Health
dc.format.extent10
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsAcesso aberto
dc.titlePeptides of the Constant Region of Antibodies Display Fungicidal Activityen
dc.typeArtigo
dc.contributor.institutionUniv Parma
dc.contributor.institutionIst Super Sanita
dc.contributor.institutionUniv Perugia
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniv Parma, Dipartimento Patol & Med Lab, Sez Microbiol, I-43100 Parma, Italy
dc.description.affiliationUniv Parma, Dipartimento Patol & Med Lab, Sez Anat & Istol Patol, I-43100 Parma, Italy
dc.description.affiliationUniv Parma, Dipartimento Genet Biol Microrganismi Antropol, I-43100 Parma, Italy
dc.description.affiliationIst Super Sanita, Dipartimento Malattie Infettive Parassitarie & Im, I-00161 Rome, Italy
dc.description.affiliationUniv Perugia, Dipartimento Med Sperimentale & Sci Biochim, Sez Microbiol, I-06100 Perugia, Italy
dc.description.affiliationUniversidade Federal de São Paulo, Unidade Oncol Expt, Dept Microbiol Imunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Biol Celular, Dept Microbiol Imunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Microbiol, BR-05508 São Paulo, Brazil
dc.description.affiliationUniv Parma, Dipartimento Med Sperimentale, I-43100 Parma, Italy
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Unidade Oncol Expt, Dept Microbiol Imunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Biol Celular, Dept Microbiol Imunol & Parasitol, São Paulo, Brazil
dc.description.sponsorshipIDItalian Ministry of Health: 40H39
dc.identifier.fileWOS000303857100067.pdf
dc.identifier.doi10.1371/journal.pone.0034105
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000303857100067
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