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Title: Case Report: Disseminated Sporothrix brasiliensis Infection with Endocardial and Ocular Involvement in an HIV-Infected Patient
Authors: Silva-Vergara, Mario Leon
Camargo, Zoilo Pires de [UNIFESP]
Silva, Patricia Ferreira
Abdalla, Michel Reis
Sgarbieri, Ricardo Nilsson
Rodrigues, Anderson Messias
Santos, Keila Cristina dos
Barata, Cristina Hueb
Ferreira-Paim, Kennio
Fed Univ Tricingulo Mineiro
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Mar-2012
Publisher: Amer Soc Trop Med & Hygiene
Citation: American Journal of Tropical Medicine and Hygiene. Mclean: Amer Soc Trop Med & Hygiene, v. 86, n. 3, p. 477-480, 2012.
Abstract: Disseminated sporotrichosis occurs in individuals with impaired cellular immunity, such as in cases of neoplasia, transplantation, diabetes, and especially, acquired immunodeficiency syndrome. This report presents a 32-year-old Brazilian human immunodeficiency virus (HIV)-infected patient who developed a protracted condition of disseminated sporotrichosis with endocarditis, bilateral endophthalmitis, and lymphatic involvement. He needed cardiac surgery to replace the mitral valve. Sporothrix brasiliensis isolates were recovered from cultures of subcutaneous nodules and mitral valve fragments. Species identification was based on classical and molecular methods. the patient received amphotericin B for 52 days and subsequently, oral itraconazole. He remains asymptomatic, and he is on maintenance therapy with itraconazole. Despite his positive clinical outcome, he developed bilateral blindness. To our knowledge, this case is the first report of endocarditis and endophthalmitis caused by S. brasiliensis.
ISSN: 0002-9637
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Appears in Collections:Em verificação - Geral

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