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Title: Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy
Authors: Almeida, S. S. [UNIFESP]
Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
Guimarães, Paola Bianchi [UNIFESP]
Wasinski, F. [UNIFESP]
Pereira, F. E. G. [UNIFESP]
Canzian, Mauro [UNIFESP]
Centeno, Ricardo Silva [UNIFESP]
Carrete Junior, Henrique [UNIFESP]
Yacubian, Elza Márcia Targas [UNIFESP]
Carmona, Adriana Karaoglanovic [UNIFESP]
Vieira, Renata de Freitas Fisher [UNIFESP]
Nakaie, Clovis Ryuichi [UNIFESP]
Sabatini, R. A. [UNIFESP]
Perosa, S. R. [UNIFESP]
Bacurau, Reury Frank Pereira
Gouveia, Telma Luciana Furtado [UNIFESP]
Gallo, Gloria [UNIFESP]
Wuertele, M. [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
Silva, J. A.
Pesquero, João Bosco [UNIFESP]
Araujo, R. C. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Nove de Julho Univ UNINOVE
Keywords: angiotensin I-converting enzyme
Issue Date: 1-Mar-2012
Publisher: Nature Publishing Group
Citation: Translational Psychiatry. New York: Nature Publishing Group, v. 2, 5 p., 2012.
Abstract: We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin-angiotensin and kallikrein-kinin systems. Translational Psychiatry (2012) 2, e93; doi:10.1038/tp.2012.21; published online 13 March 2012
ISSN: 2158-3188
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