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Title: Airflow Obstruction in Never Smokers in Five Latin American Cities: the PLATINO Study
Authors: Perez-Padilla, Rogelio
Fernandez, Rosario
Lopez Varela, Maria Victorina
Montes de Oca, Maria
Muino, Adriana
Talamo, Carlos
Brito Jardim, Jose Roberto [UNIFESP]
Valdivia, Gonzalo
Baptista Menezes, Ana Maria
Inst Nacl Enfermedades Resp
Univ Republica
Cent Univ Venezuela
Universidade Federal de São Paulo (UNIFESP)
Pontificia Univ Catolica Chile
Keywords: Chronic pulmonary disease
Never smokers
Health status
Tobacco smoking
Issue Date: 1-Feb-2012
Publisher: Elsevier B.V.
Citation: Archives of Medical Research. New York: Elsevier B.V., v. 43, n. 2, p. 159-165, 2012.
Abstract: Background. Although chronic obstructive pulmonary disease (COPD) is mostly related to tobacco smoking, a variable proportion of COPD occurs in never smokers. We investigated differences between COPD in never smokers compared with smokers and subjects without COPD.Methods. PLATINO is a cross-sectional population-based study of five Latin American cities. COPD was defined as postbronchodilator FEV1/FVC <0.70 and FEV1 <80% of predicted values.Results. Among 5,315 subjects studied, 2278 were never smokers and 3036 were ever smokers. COPD was observed in 3.5% of never smokers and in 7.5% of ever smokers. Never smokers with COPD were most likely older and reported a medical diagnosis of asthma or previous tuberculosis. Underdiagnosis was as common in obstructed patients who never smoked as in ever smokers.Conclusions. Never smokers comprised 26% of all individuals with airflow obstruction. Obstruction was associated with female gender, older age and a diagnosis of asthma or tuberculosis. (C) 2012 IMSS. Published by Elsevier Inc.
ISSN: 0188-4409
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