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Title: Renal oxygen content is increased in healthy subjects after angiotensin-converting enzyme inhibition
Authors: Stein, Anna [UNIFESP]
Goldmeier, Silvia
Voltolini, Sarah
Setogutti, Enio
Feldman, Carlos
Figueiredo, Eduardo
Eick, Renato
Irigoyen, Maria
Rigatto, Katya
Fundacao Univ Cardiol IC FUC
Universidade Federal de São Paulo (UNIFESP)
Serv Invest Diagnost SIDI
MR Res Latin Amer GE Healthcare
Universidade de São Paulo (USP)
Keywords: BOLD
Renal Oxygenation
Healthy Subjects
Renin-Angiotensin System
Issue Date: 1-Jan-2012
Publisher: Hospital Clinicas, Univ São Paulo
Citation: Clinics. São Paulo: Hospital Clinicas, Univ São Paulo, v. 67, n. 7, p. 761-765, 2012.
Abstract: OBJECTIVE: the association between renal hypoxia and the development of renal injury is well established. However, no adequate method currently exists to non-invasively measure functional changes in renal oxygenation in normal and injured patients.METHOD: R2(star) quantification was performed using renal blood oxygen level-dependent properties. Five healthy normotensive women (50 +/- 5.3 years) underwent magnetic resonance imaging in a 1.5T Signa Excite HDx scanner (GE Healthcare, Waukesha, WI). A multiple fast gradient-echo sequence was used to acquire R2(star)/T-2(star) images (sixteen echoes from 2.1 ms/slice to 49.6 ms/slice in a single breath hold per location). the images were post-processed to generate R2(star) maps for quantification. Data were recorded before and at 30 minutes after the oral administration of an angiotensin II-converting enzyme inhibitor (captopril, 25 mg). the results were compared using an ANOVA for repeated measurements (mean +/- standard deviation) followed by the Tukey test. NCT01545479.RESULTS: A significant difference (p<0.001) in renal oxygenation (R2(star)) was observed in the cortex and medulla before and after captopril administration: right kidney, cortex = 11.08 +/- 0.56ms, medulla = 17.21 +/- 1.47ms and cortex = 10.30 +/- 0.44ms, medulla = 16.06 +/- 1.74ms, respectively; and left kidney, cortex = 11.79 +/- 1.85ms, medulla = 17.03 +/- 0.88ms and cortex = 10.89 +/- 0.91ms, medulla = 16.43 +/- 1.49ms, respectively.CONCLUSIONS: This result suggests that the technique efficiently measured alterations in renal blood oxygenation after angiotensin II-converting enzyme inhibition and that it may provide a new strategy for identifying the early stages of renal disease and perhaps new therapeutic targets.
ISSN: 1807-5932
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