Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/34367
Title: Cancer/Testis Antigen MAGE-C1/CT7: New Target for Multiple Myeloma Therapy
Authors: Carvalho, Fabricio de [UNIFESP]
Vettore, Andre L. [UNIFESP]
Colleoni, Gisele W. B. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Jan-2012
Publisher: Hindawi Publishing Corporation
Citation: Clinical & Developmental Immunology. New York: Hindawi Publishing Corporation, 7 p., 2012.
Abstract: Cancer/Testis Antigens (CTAs) are a promising class of tumor antigens that have a limited expression in somatic tissues (testis, ovary, fetal, and placental cells). Aberrant expression of CTAs in cancer cells may lead to abnormal chromosome segregation and aneuploidy. CTAs are regulated by epigenetic mechanisms (DNA methylation and acetylation of histones) and are attractive targets for immunotherapy in cancer because the gonads are immune privileged organs and anti-CTA immune response can be tumor-specific. Multiple myeloma (MM) is an incurable hematological malignancy, and several CTAs have been detected in many MM cell lines and patients. Among CTAs expressed in MM we must highlight the MAGE-C1/CT7 located on the X chromosome and expressed specificity in the malignant plasma cells. MAGE-C1/CT7 seems to be related to disease progression and functional studies suggests that this CTA might play a role in cell cycle and mainly in survival of malignant plasma cells, protecting myeloma cells against spontaneous as well as drug-induced apoptosis.
URI: http://repositorio.unifesp.br/handle/11600/34367
ISSN: 1740-2522
Other Identifiers: http://dx.doi.org/10.1155/2012/257695
Appears in Collections:Artigo

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