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Title: Bupivacaine Injection Leads to Muscle Force Reduction and Histologic Changes in a Murine Model
Authors: McNeill Ingham, Sheila Jean [UNIFESP]
Pochini, Alberto de Castro [UNIFESP]
Oliveira, Daniel Antonio de [UNIFESP]
Garcia Lisboa, Bianca Cristina [UNIFESP]
Beutel, Abram [UNIFESP]
Valero-Lapchik, Valderez Bastos [UNIFESP]
Ferreira, Ana Maria
Abdalla, Rene Jorge [UNIFESP]
Cohen, Moises [UNIFESP]
Han, Sang Won [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal Fluminense (UFF)
Issue Date: 1-Dec-2011
Publisher: Elsevier B.V.
Citation: Pm&r. New York: Elsevier B.V., v. 3, n. 12, p. 1106-1109, 2011.
Abstract: Objective: To evaluate the effect of bupivacaine on muscle force and histology. We hypothesize that bupivacaine will worsen the muscle's physiological activity.Setting: Controlled laboratory experiment.Methods: Bupivacaine (0.5 mL, 0.5%) was injected into the mid belly and distal portions of the right gastrocnemius in 32 Wistar male rats (the left gastrocnemius was used as a control). After 5, 14, 21, and 28 days, in groups of 4, muscle force was evaluated and the animals were euthanized by an overdose of anesthetic for histologic evaluation. One-way analysis of variance was used to analyze data from force and weight measurements. Only the values of P < .05 were considered to be statistically significant.Results: Bupivacaine causes a process of degeneration-regeneration of the muscle fibers and it also causes a reduction in muscle force, which is significant at 2 and 3 weeks and does not normalize at 4 weeks. the muscle injury is obvious after 5 days, and the degenerative process is predominant at 2 and 3 weeks. We found an increase in muscle mass in the acute phase and a decrease in muscle force.Conclusion: Although our results do not allow a direct clinical application, we believe that caution should be warranted when intramuscular bupivacaine is used. PM R 2011;3:1106-1109
ISSN: 1934-1482
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