Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/34298
Title: Neurocutaneous melanosis: Follow-up and literature review
Authors: Scattolin, M. A. A. [UNIFESP]
Lin, J. [UNIFESP]
Peruchi, M. M.
Rocha, A. J.
Masruha, M. R. [UNIFESP]
Vilanova, L. C. P. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Santa Casa de Misericordia São Paulo
Keywords: Neurocutaneous melanosis
Giant melanocytic nevus
Children
Issue Date: 1-Dec-2011
Publisher: Masson Editeur
Citation: Journal of Neuroradiology. Moulineaux Cedex 9: Masson Editeur, v. 38, n. 5, p. 313-318, 2011.
Abstract: Neurocutaneous melanosis is a rare, congenital, non-inherited syndrome characterized by numerous and/or large congenital nevi with intracranial leptomeningeal melanocytosis. This report describes two patients, presenting with a giant congenital nevus involving, a major portion of the posterior trunk with satellite congenital nevi scattered all over the body, who developed seizures at 4 and 6 months of age, respectively. Changes in follow-up magnetic resonance (MR) examinations over an 8-year period were seen in case 1, while parenchymal melanocytic accumulation was reported in the region of the amygdala in case 2. These cases emphasize that neurocutaneous melanosis should be suspected in patients with giant congenital nevus with or without neurological symptoms. Also, neuroaxial MR screening should be performed in all cases and, ideally, before myelination of the brain to provide the highest sensitivity for detecting melanin deposits in the leptomeninges. (C) 2011 Elsevier Masson SAS. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/34298
ISSN: 0150-9861
Other Identifiers: http://dx.doi.org/10.1016/j.neurad.2011.02.007
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