Please use this identifier to cite or link to this item:
|Title:||Reduced cerebellar left hemisphere and vermal volume in adults with PTSD from a community sample|
|Authors:||Baldacara, Leonardo [UNIFESP]|
Jackowski, Andrea P.
Schoedl, Aline [UNIFESP]
Pupo, Mariana [UNIFESP]
Andreoli, Sergio B. [UNIFESP]
Mello, Marcelo F. [UNIFESP]
Lacerda, Acioly L. T.
Mari, Jair J.
Bressan, Rodrigo A.
Universidade Federal de São Paulo (UNIFESP)
Posttraumatic stress disorder
Magnetic resonance imaging
|Citation:||Journal of Psychiatric Research. Oxford: Pergamon-Elsevier B.V., v. 45, n. 12, p. 1627-1633, 2011.|
|Abstract:||Background: Traumatic events exposure is a necessary condition for developing posttraumatic stress disorder (PTSD), but not all individuals exposed to the same trauma will develop PTSD. Human studies have suggested that the cerebellum is involved in human fear perception, anticipation, and recollection. in this context, the current study evaluated whether cerebellar volume is associated with PTSD.Methods: Eighty-four victims of violence, 42 who fulfilled the DSM-IV-TR criteria for PTSD and 42 resilient controls, were identified through an epidemiologic survey conducted in the city of 530 Paulo. Subjects were evaluated using the Clinician-Administered PTSD Scale (CAPS), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Early Trauma Inventory (ETI). All subjects underwent a magnetic resonance imaging (MRI) scan to evaluate their cerebellar hemispheres and vermis.Results: PTSD subjects had relative smaller left hemisphere (p = 0.04) and vermis (p < 0.01) volumes persisted after controlling for gender, age, and brain volume. in PTSD group, left cerebellar hemisphere volume correlated negatively with PTSD (p = 0.01) and depressive symptoms (p = 0.04). Vermal volume correlated negatively with PTSD symptoms (p < 0.01), early traumatic life events (p < 0.01), depressive symptoms (p = 0.04) and anxiety (p = 0.01).Conclusion: the cerebellum is involved in emotion modulation, and our results suggest that cerebellar volumetric reduction is associated with mood, anxiety and PTSD symptoms. Early traumatic life experiences are related to vermal volume reduction and may be a risk factor for future PTSD development. (C) 2011 Elsevier B.V. All rights reserved.|
|Appears in Collections:||Em verificação - Geral|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.