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Title: Immunolocalization of IFN-gamma in the lesions of resistant and susceptible mice to Paracoccidioides brasiliensis infection
Authors: Nishikaku, Angela Satie [UNIFESP]
Sanchez Molina, Raphael Fagnani
Albe, Bernardo Paulo
Cunha, Claudia da Silva
Scavone, Renata
Pinto Pizzo, Celia Regina
Camargo, Zoilo Pires de [UNIFESP]
Burger, Eva
Univ Fed Alfenas
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Keywords: interferon-gamma
experimental paracoccidioidomycosis
resistant and susceptible mice
Issue Date: 1-Nov-2011
Publisher: Wiley-Blackwell
Citation: Fems Immunology and Medical Microbiology. Malden: Wiley-Blackwell, v. 63, n. 2, p. 281-288, 2011.
Abstract: The important role of interferon-gamma (IFN-gamma) in protective immunity in mycosis is well established, except for its participation in fungal granulomas. Herein, we employ immunohistochemical reactions to describe the in situ localization of IFN-gamma in granulomas of susceptible (B10.A) and resistant (A/J) mice to infection with Paracoccidioides brasiliensis (Pb). After infection with the highly virulent Pb18, IFN-gamma-positive lymphomononuclear cells were localized mainly at the periphery of granulomas in both mouse strains. the numbers of positive cells found in compact granulomas of A/J mice increased significantly from 15 to 120 days postinfection. At this time, significantly more positive cells were detected in the compact granulomas of resistant mice than in the loose, multifocal lesions of the susceptible ones. in infection with the slightly virulent Pb265, the same pattern of IFN-gamma localization was found as in Pb18 infection, but there was decreased staining at 120 days due to the presence of only residual lesions in both mouse strains. the marked IFN-gamma staining observed in the granulomas of resistant mice at the later stage of Pb infection confirms its importance in fungal dissemination control, and suggests a contribution to the development of paracoccidioidal granuloma.
ISSN: 0928-8244
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Appears in Collections:Em verificação - Geral

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