Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/34152
Title: Nandrolone and resistance training induce heart remodeling: Role of fetal genes and implications for cardiac pathophysiology
Authors: Tanno, Ana Paula
Neves, Vander José das
Rosa, Kaleizu Teodoro
Cunha, Tatiana Sousa [UNIFESP]
Linarello Giordano, Fernanda Cristina
Calil, Caroline Morini
Guzzoni, Vinicius
Fernandes, Tiago
Oliveira, Edilamar Menezes de
Novaes, Pedro Duarte
Irigoyen, Maria Claudia [UNIFESP]
Moura, Maria José Costa Sampaio
Marcondes, Fernanda Klein
Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Keywords: Cardiac hypertrophy
Genes
Training
Collagen
Echocardiography
Nandrolone
Issue Date: 24-Oct-2011
Publisher: Elsevier B.V.
Citation: Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 89, n. 17-18, p. 631-637, 2011.
Abstract: Aims: This study was conducted to assess the isolated and combined effects of nandrolone and resistance training on cardiac morphology, function, and mRNA expression of pathological cardiac hypertrophy markers.Main methods: Wistar rats were randomly divided into four groups and submitted to 6 weeks of treatment with nandrolone and/or resistance training. Cardiac parameters were determined by echocardiography. Heart was analyzed for collagen infiltration. Real-time RT-PCR was used to assess the pathological cardiac hypertrophy markers.Key findings: Both resistance training and nandrolone induced cardiac hypertrophy. Nandrolone increased the cardiac collagen content, and reduced the cardiac index in non-trained and trained groups, when compared with the respective vehicle-treated groups. Nandrolone reduced the ratio of maximum early to late transmitral flow velocity in non-trained and trained groups, when compared with the respective vehicle-treated groups. Nandrolone reduced the alpha-myosin heavy chain gene expression in both non-trained and trained groups, when compared with the respective vehicle-treated groups. Training reduced the beta-myosin heavy chain gene expression in the groups treated with vehicle and nandrolone. Only the association between training and nandrolone increased the expression of the skeletal alpha-actin gene and atrial natriuretic peptide in the left ventricle.Significance: This study indicated that nandrolone, whether associated with resistance training or not, induces cardiac hypertrophy, which is associated with enhanced collagen content, re-expression of fetal genes the in left ventricle, and impaired diastolic and systolic function. (C) 2011 Elsevier Inc. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/34152
ISSN: 0024-3205
Other Identifiers: http://dx.doi.org/10.1016/j.lfs.2011.08.004
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