Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/34142
Title: Early life stress decreases hippocampal BDNF content and exacerbates recognition memory deficits induced by repeated D-amphetamine exposure
Authors: Martins de Lima, Maria Noemia
Presti-Torres, Juliana
Vedana, Gustavo
Alcalde, Luisa Azambuja
Stertz, Laura
Fries, Gabriel Rodrigo
Roesler, Rafael
Andersen, Monica Levy [UNIFESP]
Quevedo, Joao
Kapczinski, Flavio
Schroeder, Nadja
Pontifical Catholic Univ
Univ Fed Rio Grande do Sul
Universidade Federal de São Paulo (UNIFESP)
Univ So Santa Catarina
Natl Inst Translat Med INCT TM
Keywords: Maternal deprivation
D-Amphetamine
Recognition memory
Brain-derived neurotrophic factor
Psychostimulant
Rat
Issue Date: 10-Oct-2011
Publisher: Elsevier B.V.
Citation: Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 224, n. 1, p. 100-106, 2011.
Abstract: Adverse experiences early in life may have profound influences on brain development, for example, determining alterations in response to psychostimulant drugs, an increased risk of developing a substance abuse disorder, and individual differences in the vulnerability to neuropsychiatric disorders later in life. Here, we investigated the effects of exposure to an early adverse life event, maternal deprivation, combined with repeated D-amphetamine (AMPH) administration in adulthood, on recognition memory and brain-derived neurotrophic factor (BDNF) levels in rats' brain and serum. Rats were exposed to one of the following maternal rearing conditions from postnatal days 1 to 14: non-deprived (ND) or deprived (D). in adulthood, both groups received injections of saline (SAL) or AMPH (2.0 mg/kg, i.p.) for 7 days. in Experiment I (performed 24 h after the last AMPH injection), AMPH induced long-term memory (LTM) impairments in ND and D groups. the D + AMPH group also presented short-term memory (STM) impairments, indicating that the effects of AMPH on memory were more pronounced when the animals where maternally deprived. the group exposed to D + SAL (SAL) showed only LTM impairments. in Experiment II (performed 8 days after the last injection), AMPH detrimental effects on memory persisted in ND and D groups. BDNF levels were decreased in the hippocampus of D + SAL rats. in conclusion, AMPH produces severe and persistent recognition memory impairments that were more pronounced when the animals were maternally deprived, suggesting that an early adverse life event may increase the vulnerability of cognitive function to exposure to a psychostimulant later in life. (C) 2011 Elsevier B.V. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/34142
ISSN: 0166-4328
Other Identifiers: http://dx.doi.org/10.1016/j.bbr.2011.05.022
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