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Title: Acute Hepatitis C in Brazil: Results of a National Survey
Authors: Paiva Ferreira, Adalgisa de Souza
Perez, Renata de Mello
Gomes Ferraz, Maria Lucia [UNIFESP]
Lewis-Ximenez, Lia Laura
Pereira, Joao Luis
Lerias de Almeida, Paulo Roberto
Mattos, Angelo Alves de
Acute Hepatitis C Study Grp Brazil
Univ Fed Maranhao
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Osvaldo Cruz Fdn
Gen Hosp Bonsucesso
Nossa Senhora Conceicao Hosp
Fed Fdn Sch Med Sci
Keywords: acute hepatitis C
risk factors
Issue Date: 1-Oct-2011
Publisher: Wiley-Blackwell
Citation: Journal of Medical Virology. Malden: Wiley-Blackwell, v. 83, n. 10, p. 1738-1743, 2011.
Abstract: The incidence of acute hepatitis C has decreased in the world. However, new cases are still reported. the objective of this study was to obtain data of acute hepatitis C in Brazil and to identify risk factors of transmission, diagnostic criteria, clinical presentation, evolution, and treatment. A questionnaire was sent to all members of the Brazilian Society of Hepatology. Sixteen centers participated with a total of 170 cases between 2000 and 2008. Among them, 37 had chronic renal failure on hemodialysis and were evaluated separately. the main diagnostic criterion in non-uremic patients was ALT (alanine aminotransferase) elevation associated with risk factors. in patients with chronic renal failure, anti-hepatitis C virus (HCV) sero-conversion was the most frequent criterion. Among the 133 non-uremic patients the main risk factors were hospital procedures, whereas in hemodialysis patients, dialysis was the single risk factor in 95% of the cases. Jaundice was more frequent in non-uremic patients (82% vs. 13%; P < 0.001) and ALT levels were higher in these individuals (P < 0.001). Spontaneous clearance was more frequent in non-uremic patients (51% vs. 3%; P < 0.001). Sixty-five patients were treated: 39 non-urennic patients and 26 on dialysis. Sustained virological response rates were 60% for non-uremic and 58% for uremic patients (P = 0.98). There was no association of these rates with the study variables. These findings show that cases of acute hepatitis C are still occurring and have been related predominantly to hospital procedures. Measures to prevent nosocomial transmission should be adopted rigorously and followed to minimize this important source of infection observed in this survey. J. Med. Virol. 83:1738-1743, 2011. (C) 2011 Wiley-Liss, Inc. J. Med.
ISSN: 0146-6615
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