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Title: Polymorphisms of Estrogen Receptors Alpha and Beta in Idiopathic, Infertile Brazilian Men: A Case-Control Study
Authors: Bianco, Bianca
Peluso, Carla
Gava, Marcello Machado
Ghirelli-Filho, Milton
Nunes Lipay, Monica Vannucci [UNIFESP]
Lipay, Marco Aurelio
Christofolini, Denise Maria
Barbosa, Caio Parente
Fac Med ABC
Universidade Federal de São Paulo (UNIFESP)
Fac Med Jundiai
Santa Helena Hosp
Issue Date: 1-Sep-2011
Publisher: Wiley-Blackwell
Citation: Molecular Reproduction and Development. Malden: Wiley-Blackwell, v. 78, n. 9, p. 665-672, 2011.
Abstract: Estrogen plays an important role in the human reproductive system and its action is mediatedmainly by two specific receptors: alpha(ER alpha) and beta(ER beta). There are polymorphic variants in both ER genes, and studies showed their association with reproductive outcomes. We aimed to determine the distribution of ER alpha and ER beta gene polymorphisms in idiopathic, infertile Brazilian patients in a case-control study comprising 187 idiopathic, infertile Brazilian men with nonobstructive azoospermia (NOA, n = 78) or severe oligozoospermia(SO, n 109) and 216 fertile men. Detection of ER alpha (PvuII and XbaI) and ER beta (AluI and RsaI) gene polymorphisms were performed using TaqMan PCR. the results were analyzed statically, and a P-value < 0.05 was considered significant. Single-marker analysis revealed that neither PvuII nor XbaI polymorphisms of the ER alpha gene were associated either with NOA group (P = 0.662 and P = 0.527, respectively) or SO group (P = 0.777 and P = 1.0, respectively). Regarding ER beta polymorphisms, no statistical difference was observed between the AluI polymorphism and NOA group compared to controls (P 1.0) or between SO group and controls (P = 0.423). We found similar results with the RsaI polymorphism. Statistical analysis did not reveal a difference between NOA (P = 0.740) and SO (P = 0.920) groups compared to controls. Combined genotypes of ER alpha and ER beta polymorphisms did not identify a haplotype associated with idiopathic infertility. Thus, in the Brazilian population, genetic variations in both estrogen receptors alpha (PvuII and XbaI) and beta (AluI and RsaI) were not relevant to idiopathic infertility. Mol. Reprod. Dev. 78: 665-672, 2011. (C) 2011 Wiley-Liss, Inc.
ISSN: 1040-452X
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