Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/33958
Title: Antiretroviral Drug Resistance in a Respondent-Driven Sample of HIV-Infected Men Who Have Sex With Men in Brazil
Authors: Bermudez-Aza, Elkin Hernan [UNIFESP]
Franco Sansigolo Kerr, Ligia Regina
Kendall, Carl
Pinho, Adriana Araujo
Mello, Maeve Brito de
Mota, Rosa Salani
Crosland Guimaraes, Mark Drew
Alencar, Cecilia Salete [UNIFESP]
Brito, Ana Maria de
Dourado, Ines Costa
Batista da Batista, Sonia Maria
Abreu, Fabiano
Oliveira, Lisangela Cristina de
Moraes, Adao de Souza
Benzaken, Adele Schwartz
Merchan-Hamann, Edgar
Brandao de Freitas, Gisele Maria
McFarland, Willi
Albuquerque, Elizabeth
Rutherford, George W.
Sabino, Ester [UNIFESP]
Univ Fed Ceara
Universidade Federal de São Paulo (UNIFESP)
Tulane Univ
Universidade Federal de Minas Gerais (UFMG)
Universidade Federal da Bahia (UFBA)
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade de Brasília (UnB)
Univ Calif San Francisco
Universidade de São Paulo (USP)
Keywords: HIV-1
men who have sex with men
respondent-driven sampling
Brazil
antiretroviral resistance
Issue Date: 15-Aug-2011
Publisher: Lippincott Williams & Wilkins
Citation: Jaids-Journal of Acquired Immune Deficiency Syndromes. Philadelphia: Lippincott Williams & Wilkins, v. 57, p. S186-S192, 2011.
Abstract: Background: There are few studies on HIV subtypes and primary and secondary antiretroviral drug resistance (ADR) in community-recruited samples in Brazil. We analyzed HIV clade diversity and prevalence of mutations associated with ADR in men who have sex with men in all five regions of Brazil.Methods: Using respondent-driven sampling, we recruited 3515 men who have sex with men in nine cities: 299 (9.5%) were HIV-positive; 143 subjects had adequate genotyping and epidemiologic data. Forty-four (30.8%) subjects were antiretroviral therapy-experienced (AE) and 99 (69.2%) antiretroviral therapy-naive (AN). We sequenced the reverse transcriptase and protease regions of the virus and analyzed them for drug resistant mutations using World Health Organization guidelines.Results: the most common subtypes were B (81.8%), C (7.7%), and recombinant forms (6.9%). the overall prevalence of primary ADR resistance was 21.4% (i.e. among the AN) and secondary ADR was 35.8% (i.e. among the AE). the prevalence of resistance to protease inhibitors was 3.9% (AN) and 4.4% (AE); to nucleoside reverse transcriptase inhibitors 15.0% (AN) and 31.0% (AE) and to nonnucleoside reverse transcriptase inhibitors 5.5% (AN) and 13.2% (AE). the most common resistance mutation for nucleoside reverse transcriptase inhibitors was 184V (17 cases) and for nonnucleoside reverse transcriptase inhibitors 103N (16 cases).Conclusions: Our data suggest a high level of both primary and secondary ADR in men who have sex with men in Brazil. Additional studies are needed to identify the correlates and causes of antiretroviral therapy resistance to limit the development of resistance among those in care and the transmission of resistant strains in the wider epidemic.
URI: http://repositorio.unifesp.br/handle/11600/33958
ISSN: 1525-4135
Other Identifiers: http://dx.doi.org/10.1097/QAI.0b013e31821e9c36
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