Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/33927
Title: Sleep and muscle recovery: Endocrinological and molecular basis for a new and promising hypothesis
Authors: Dattilo, Murilo [UNIFESP]
Antunes, Hanna Karen Moreira [UNIFESP]
Medeiros, Alessandra [UNIFESP]
Mônico-Neto, Marcos [UNIFESP]
Souza, Heitor Soares de [UNIFESP]
Tufik, Sergio [UNIFESP]
Mello, Marco Tulio de [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
CEPE
Issue Date: 1-Aug-2011
Publisher: Churchill Livingstone
Citation: Medical Hypotheses. Edinburgh: Churchill Livingstone, v. 77, n. 2, p. 220-222, 2011.
Abstract: Sleep is essential for the cellular, organic and systemic functions of an organism, with its absence being potentially harmful to health and changing feeding behavior, glucose regulation, blood pressure, cognitive processes and some hormonal axes. Among the hormonal changes, there is an increase in cortisol (humans) and corticosterone (rats) secretion, and a reduction in testosterone and Insulin-like Growth Factor 1, favoring the establishment of a highly proteolytic environment. Consequently, we hypothesized that sleep debt decreases the activity of protein synthesis pathways and increases the activity of degradation pathways, favoring the loss of muscle mass and thus hindering muscle recovery after damage induced by exercise, injuries and certain conditions associated with muscle atrophy, such as sarcopenia and cachexia. (C) 2011 Elsevier B.V. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/33927
ISSN: 0306-9877
Other Identifiers: http://dx.doi.org/10.1016/j.mehy.2011.04.017
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.