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Title: The relationship between the Trp 64 Arg polymorphism of the beta 3-adrenoceptor gene and idiopathic overactive bladder
Authors: Ferreira, Cristina E. [UNIFESP]
Fonseca, Andrea M.
Silva, Ismael D. [UNIFESP]
Girao, Manoel J. [UNIFESP]
Sartori, Marair G. [UNIFESP]
Castro, Rodrigo A. [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Minas Gerais (UFMG)
Keywords: beta 3-adrenoceptor
overactive bladder
Issue Date: 1-Jul-2011
Publisher: Elsevier B.V.
Citation: American Journal of Obstetrics and Gynecology. New York: Mosby-Elsevier, v. 205, n. 1, 5 p., 2011.
Abstract: OBJECTIVE: the purpose of this study was to verify the association between the Trp 64 Arg polymorphism and idiopathic overactive bladder (OAB) syndrome.STUDY DESIGN: A case-control study was conducted with 218 women. the case group consisted of 49 patients with OAB symptoms; the control group included 169 women without urinary symptoms. the studied polymorphism was detected by restriction fragment length polymorphism analysis. the chi(2) test was used to compare categoric data, with a significance level of 5%. Numeric data were compared with the use of the parametric t test or non-parametric Mann-Whitney U test.RESULTS: the distribution of the polymorphism in the investigated women was digested homozygous T allele 69.75%, heterozygotes 29.8%, and homozygous A allele 0.45%. A comparison between the groups showed higher prevalence of the digested homozygous T allele genotype in women with OAB syndrome (P = .001). Multiple logistic regression analysis identified that a family history of OAB syndrome was an independent risk factor for OAB syndrome.CONCLUSION: the Trp 64 Arg polymorphism was associated with OAB syndrome in the Brazilian population.
ISSN: 0002-9378
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