Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/33846
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dc.contributor.authorToledo, Silvia Regina Caminada de [UNIFESP]
dc.contributor.authorZago, Marco Antonio
dc.contributor.authorOliveira, Indhira Dias [UNIFESP]
dc.contributor.authorProto-Siqueira, Rodrigo
dc.contributor.authorOkamoto, Oswaldo K.
dc.contributor.authorSeverino, Patricia
dc.contributor.authorVencio, Ricardo Z. N.
dc.contributor.authorGamba, Francine Tesser [UNIFESP]
dc.contributor.authorSilva, Wilson A.
dc.contributor.authorMoreira-Filho, Carlos A.
dc.contributor.authorDalla Torre, Cristiane Arruda [UNIFESP]
dc.contributor.authorSeixas Alves, Maria Tereza [UNIFESP]
dc.contributor.authorGarcia-Filho, Reynaldo J. [UNIFESP]
dc.contributor.authorSimpson, Andrew J. G.
dc.contributor.authorPetrilli, Antonio Sergio [UNIFESP]
dc.date.accessioned2016-01-24T14:16:56Z
dc.date.available2016-01-24T14:16:56Z
dc.date.issued2011-07-01
dc.identifierhttp://dx.doi.org/10.1007/s00776-011-0106-7
dc.identifier.citationJournal of Orthopaedic Science. Tokyo: Springer Tokyo, v. 16, n. 4, p. 458-466, 2011.
dc.identifier.issn0949-2658
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33846
dc.description.abstractOsteosarcoma (OS) is the most frequent bone tumor in children and adolescents. Tumor antigens are encoded by genes that are expressed in many types of solid tumors but are silent in normal tissues, with the exception of placenta and male germ-line cells. It has been proposed that antigen tumors are potential tumor markers.The premise of this study is that the identification of novel OS-associated transcripts will lead to a better understanding of the events involved in OS pathogenesis and biology.We analyzed the expression of a panel of seven tumor antigens in OS samples to identify possible tumor markers. After selecting the tumor antigen expressed in most samples of the panel, gene expression profiling was used to identify osteosarcoma-associated molecular alterations. A microarray was employed because of its ability to accurately produce comprehensive expression profiles.PRAME was identified as the tumor antigen expressed in most OS samples; it was detected in 68% of the cases. Microarray results showed differences in expression for genes functioning in cell signaling and adhesion as well as extracellular matrix-related genes, implying that such tumors could indeed differ in regard to distinct patterns of tumorigenesis.The hypothesis inferred in this study was gathered mostly from available data concerning other kinds of tumors. There is circumstantial evidence that PRAME expression might be related to distinct patterns of tumorigenesis. Further investigation is needed to validate the differential expression of genes belonging to tumorigenesis-related pathways in PRAME-positive and PRAME-negative tumors.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipGRAACC (Grupo de Apoio ao Adolescente e Crianca com Cancer)
dc.format.extent458-466
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Orthopaedic Science
dc.rightsAcesso restrito
dc.titleInsights on PRAME and osteosarcoma by means of gene expression profilingen
dc.typeArtigo
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionAlbert Einstein Res & Educ Inst
dc.contributor.institutionLudwig Inst
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Pediat Oncol Inst GRAACC, Dept Pediat,Genet Lab, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Clin Med, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Ctr Cellbased Therapy, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Genet & Evolutionary Biol, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationAlbert Einstein Res & Educ Inst, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Genet, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Pediat, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Orthoped Surg & Traumatol, BR-04023062 São Paulo, Brazil
dc.description.affiliationLudwig Inst, New York, NY USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Pediat Oncol Inst GRAACC, Dept Pediat,Genet Lab, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Orthoped Surg & Traumatol, BR-04023062 São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 04/12150-8
dc.description.sponsorshipIDFAPESP: 07/53869-3
dc.identifier.doi10.1007/s00776-011-0106-7
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000293001600019
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