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Title: Acute exhaustive exercise regulates IL-2, IL-4 and MyoD in skeletal muscle but not adipose tissue in rats
Authors: Rosa Neto, Jose C. [UNIFESP]
Lira, Fabio Santos de [UNIFESP]
Zanchi, Nelo E.
Oyama, Lila Missae [UNIFESP]
Pimentel, Gustavo D. [UNIFESP]
Santos, Ronaldo V. T. [UNIFESP]
Seelaender, Marilia
Nascimento, Claudia Maria da Penha Oller do [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Issue Date: 13-Jun-2011
Publisher: Biomed Central Ltd
Citation: Lipids in Health and Disease. London: Biomed Central Ltd, v. 10, 6 p., 2011.
Abstract: Background: the purpose of this study was to evaluate the effect of exhaustive exercise on proteins associated with muscle damage and regeneration, including IL-2, IL-4 and MyoD, in extensor digitorum longus (EDL) and soleus muscles and mesenteric (MEAT) and retroperitoneal adipose tissues (RPAT).Methods: Rats were killed by decapitation immediately (E0 group, n = 6), 2 (E2 group, n = 6) or 6 (E6 group, n = 6) hours after the exhaustion protocol, which consisted of running on a treadmill at approximately 70% of VO(2max) for fifty minutes and then at an elevated rate that increased at one m/min every minute, until exhaustion.Results: the control group (C group, n = 6) was not subjected to exercise. IL-2 protein expression increased at E0 in the soleus and EDL; at E2, this cytokine returned to control levels in both tissues. in the soleus, IL-2 protein expression was lower than that in the control at E6. IL-4 protein levels increased in EDL at E6, but the opposite result was observed in the soleus. MyoD expression increased at E6 in EDL.Conclusion: Exhaustive exercise was unable to modify IL-2 and IL-4 levels in MEAT and RPAT. the results show that exhaustive exercise has different effects depending on which muscle is analysed.
ISSN: 1476-511X
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