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Title: Expression of Bone Morphogenetic Protein-1 in vaginal tissue of women with severe pelvic organ prolapse
Authors: Bortolini, Maria A. T. [UNIFESP]
Shynlova, Oksana
Drutz, Harold P.
Girao, Manoel J. B. C. [UNIFESP]
Castro, Rodrigo A. [UNIFESP]
Lye, Stephen
Alarab, May
Univ Toronto
Mt Sinai Hosp
Universidade Federal de São Paulo (UNIFESP)
Keywords: Bone Morphogenetic Protein-1
extracellular matrix
pelvic organ prolapse
procollagen C proteinase
Issue Date: 1-Jun-2011
Publisher: Elsevier B.V.
Citation: American Journal of Obstetrics and Gynecology. New York: Mosby-Elsevier, v. 204, n. 6, 8 p., 2011.
Abstract: OBJECTIVES: To analyze the differential gene and protein expression of Bone Morphogenetic Protein-1 in vaginal tissue of women with advanced pelvic organ prolapse and controls.STUDY DESIGN: We sampled the anterior vaginal wall of 39 premenopausal (23 patients and 16 controls), and 18 postmenopausal women (13 patients and 5 controls) during hysterectomy. Total mRNAs and proteins were quantified by real-time RT-PCR and immunoblotting.RESULTS: Bone Morphogenetic Protein-1 gene expression was decreased in pre- and postmenopausal pelvic organ prolapse patients compared with asymptomatic women (P = .01). the expression of 130 kDa, 92.5 kDa, and 82.5 kDa isoforms of Bone Morphogenetic Protein-1 were down-regulated in postmenopausal patients (P = .01), whereas the 130 kDa isoform expression was up-regulated in premenopausal patients (P = .009), when compared with respective controls.CONCLUSION: the Bone Morphogenetic Protein-1 expression in human vagina was altered in patients with severe pelvic organ prolapse and influenced by menopausal status. Dysregulation of Bone Morphogenetic Protein-1 may contribute for a deficient vaginal connective tissue and support.
ISSN: 0002-9378
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