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Title: A new type of Brazilian propolis: Prenylated benzophenones in propolis from Amazon and effects against cariogenic bacteria
Authors: Ishida, Vanna Francine de Castro
Negri, Giuseppina [UNIFESP]
Salatino, Antonio
Bandeir, Maria Fulgencia C. L.
Universidade de São Paulo (USP)
Univ Fed Amazonas UFAM
Universidade Federal de São Paulo (UNIFESP)
Keywords: Propolis
Cariogenic bacteria
Streptococcus mutans
Polyisoprenylated benzophenones
Issue Date: 1-Apr-2011
Publisher: Elsevier B.V.
Citation: Food Chemistry. Oxford: Elsevier B.V., v. 125, n. 3, p. 966-972, 2011.
Abstract: Ethanol extracts of four propolis samples (E1-E4) from Manaus (Brazilian Amazon) were analysed by HPLC/DAD/ESI-MS/MS and GC/EIMS. the major constituents of E2 and E4 were analysed by NMR ((1)H and (13)C) and ESI/MS/MS. the main constituents of E2 and E4 are polyprenylated benzophenones: 7-epi-nemorosone, 7-epi-clusianone (major E4 constituents), xanthochymol and gambogenone (major E2 constituents), making up a chemical profile so far unreported for Brazilian propolis. Aristhophenone, methyl insigninone, 18-ethyloxy-17-hydroxy-17,18-dihydroscrobiculatone B, and derivatives of dimethyl weddellianone A and B, propolones, and a scrobiculatone derivative, were detected as minor constituents. Triterpenoids (beta-amyrins, beta-amyrenone, lupeol and lupenone) were ubiquitous and predominant in El and E3. the extracts E2 and E4 were highly active against the cariogenic bacteria Streptococcus mitis, Streptococcus mutans and Streptococcus salivarius. E2 was more active than E4, probably due to a higher content of 2-epi-nemorosone, while the latter was richer in di-hydroxylated compounds. (C) 2010 Elsevier B.V. All rights reserved.
ISSN: 0308-8146
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