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dc.contributor.authorSilveira, Claudio [UNIFESP]
dc.contributor.authorVallochi, Adriana Lima
dc.contributor.authorSilva, Ulisses Rodrigues da
dc.contributor.authorMuccioli, Cristina [UNIFESP]
dc.contributor.authorHolland, Gary N.
dc.contributor.authorNussenblatt, Robert B.
dc.contributor.authorBelfort, Rubens [UNIFESP]
dc.contributor.authorRizzo, Luiz Vicente
dc.identifier.citationBritish Journal of Ophthalmology. London: Bmj Publishing Group, v. 95, n. 3, p. 396-400, 2011.
dc.description.abstractBackground and aims Toxoplasmic retinochoroiditis may recur months or years after the primary infection. Rupture of dormant cysts in the retina is the accepted hypothesis to explain recurrence. Here, the authors present evidence supporting the presence of Toxoplasma gondii in the peripheral blood of immunocompetent patients.Methods Direct observation by light microscopy and by immunofluorescence assay was performed, and results were confirmed by PCR amplification of parasite DNA.Results the authors studied 20 patients from Erechim, Brazil, including acute infected patients, patients with recurrent active toxoplasmic retinochoroiditis, patients with old toxoplasmic retinal scars, and patients with circulating IgG antibodies against T gondii and absence of ocular lesions. Blood samples were analysed, and T gondii was found in the blood of acutely and chronically infected patients regardless of toxoplasmic retinochoroiditis.Conclusions the results indicate that the parasite may circulate in the blood of immunocompetent individuals and that parasitaemia could be associated with the reactivation of the ocular disease.en
dc.description.sponsorshipFundacao de Amparo a Pesquisa de São Paulo
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.publisherBmj Publishing Group
dc.relation.ispartofBritish Journal of Ophthalmology
dc.rightsAcesso restrito
dc.titleToxoplasma gondii in the peripheral blood of patients with acute and chronic toxoplasmosisen
dc.contributor.institutionHosp Israelita Albert Einstein
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Calif Los Angeles
dc.contributor.institutionAlbert Einstein Jewish Inst Educ & Res
dc.contributor.institutionBrazilian Minist Sci & Technol
dc.description.affiliationHosp Israelita Albert Einstein, BR-05652000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Immunol, São Paulo, Brazil
dc.description.affiliationUniv Calif Los Angeles, Jules Stein Eye Inst, Ocular Inflammatory Dis Ctr, Los Angeles, CA 90024 USA
dc.description.affiliationUniv Calif Los Angeles, Dept Ophthalmol, David Geffen Sch Med, Los Angeles, CA 90024 USA
dc.description.affiliationNEI, Immunol Lab, NIH, Bethesda, MD 20892 USA
dc.description.affiliationAlbert Einstein Jewish Inst Educ & Res, São Paulo, Brazil
dc.description.affiliationBrazilian Minist Sci & Technol, Inst Invest Immunol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, Escola Paulista Med, São Paulo, Brazil
dc.description.sourceWeb of Science
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