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Title: Visceral fat decreased by long-term interdisciplinary lifestyle therapy correlated positively with interleukin-6 and tumor necrosis factor-alpha and negatively with adiponectin levels in obese adolescents
Authors: Lira, Fabio Santos de [UNIFESP]
Rosa Neto, José Cesar [UNIFESP]
Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]
Venancio, Daniel Paulino [UNIFESP]
Carnier, June [UNIFESP]
Sanches, Priscila de Lima [UNIFESP]
Nascimento, Claudia Maria da Penha Oller do [UNIFESP]
Piano, Aline de [UNIFESP]
Tock, Lian [UNIFESP]
Tufik, Sergio [UNIFESP]
Mello, Marco Tulio de [UNIFESP]
Dâmaso, Ana Raimunda [UNIFESP]
Oyama, Lila Missae [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Issue Date: 1-Mar-2011
Publisher: Elsevier B.V.
Citation: Metabolism-clinical and Experimental. Philadelphia: W B Saunders Co-Elsevier Inc, v. 60, n. 3, p. 359-365, 2011.
Abstract: The purpose of this study was to assess the level of cytokine expression in correlation with visceral and subcutaneous fat in obese adolescents admitted to long-term interdisciplinary weight loss therapy. the study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (18, aged 15-19 years) with body mass indexes greater than the 95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. Visceral and subcutaneous fat was analyzed by ultrasonography. Blood samples were collected to analyze tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-10 (IL-10), and adiponectin concentrations that were measured by enzyme-linked immunosorbent assay. the most important finding in the present investigation is that the long-term interdisciplinary lifestyle therapy decreased visceral fat. Positive correlations between IL-6 levels and visceral fat (r = 0.42, P < .02) and TNF-alpha levels and visceral fat (r = 0.40, P < .05) were observed. Negative correlations between TNF-alpha levels and subcutaneous fat (r = -0.46, P < .01) and adiponectin levels and subcutaneous fat (r = -0.43, P < .03) were also observed. in addition, we found a positive correlation between TNF-alpha levels and the visceral to subcutaneous fat ratio (r = 0.42, P < .02) and a negative correlation between adiponectin level and the visceral to subcutaneous fat ratio (r = -0.69, P < .001). Despite the limitation of sample size, our results indicate that the observed massive weight loss (mainly visceral fat) was highly correlated with a decreased inflammatory state, suggesting that the interdisciplinary therapy was effective in decreasing inflammatory markers. (C) 2011 Elsevier Inc. All rights reserved.
ISSN: 0026-0495
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