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dc.contributor.authorPassero, Luiz Felipe D.
dc.contributor.authorBonfim-Melo, Alexis
dc.contributor.authorCorbett, Carlos Eduardo P.
dc.contributor.authorLaurenti, Marcia D.
dc.contributor.authorToyama, Marcos H.
dc.contributor.authorToyama, Daniela O. de
dc.contributor.authorRomoff, Paulete
dc.contributor.authorFavero, Oriana A.
dc.contributor.authorGrecco, Simone S. dos [UNIFESP]
dc.contributor.authorZalewsky, Cynthia A. [UNIFESP]
dc.contributor.authorLago, Joo Henrique G. [UNIFESP]
dc.identifier.citationParasitology Research. New York: Springer, v. 108, n. 3, p. 529-536, 2011.
dc.description.abstractSpecies of Baccharis exhibit antibiotic, antiseptic, wound-healing, and anti-protozoal properties, and have been used in the traditional medicine of South America for the treatment of several diseases. in the present work, the fractionation of EtOH extract from aerial parts of Baccharis uncinella indicated that the isolated compounds caffeic acid and pectolinaringenin showed inhibitory activity against Leishmania (L.) amazonensis and Leishmania (V.) braziliensis promastigotes, respectively. Moreover, amastigote forms of both species were highly sensible to the fraction composed by oleanolic + ursolic acids and pectolinaringenin. Caffeic acid also inhibited amastigote forms of L. (L.) amazonensis, but this effect was weak in L. (V.) braziliensis amastigotes. the treatment of infected macrophages with these compounds did not alter the levels of nitrates, indicating a direct effect of the compounds on amastigote stages. the results presented herein suggest that the active components from B. uncinella can be important to the design of new drugs against American tegumentar leishmaniases.en
dc.relation.ispartofParasitology Research
dc.rightsAcesso restrito
dc.titleAnti-leishmanial effects of purified compounds from aerial parts of Baccharis uncinella C. DC. (Asteraceae)en
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Estadual Paulista
dc.contributor.institutionUniv Presbiteriana Mackenzie
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv São Paulo, Dept Patol, Lab Patol Molestias Infecciosas, Fac Med, BR-01246903 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, BR-11330900 Sao Vicente, SP, Brazil
dc.description.affiliationUniv Presbiteriana Mackenzie, Lab Quim Prod Nat, Ctr Ciencias & Humanidades, BR-01302907 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ciencias Exatas & Terra, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationUniv Presbiteriana Mackenzie, Ctr Ciencias Biol & Saude, BR-01302907 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ciencias Exatas & Terra, BR-09972270 Diadema, SP, Brazil
dc.description.sourceWeb of Science
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