Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/33416
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dc.contributor.authorScorza, Fulvio A. [UNIFESP]
dc.contributor.authorCavalheiro, Esper A. [UNIFESP]
dc.contributor.authorAlbuquerque, Marly de
dc.contributor.authorAlbuquerque, Juliana de
dc.contributor.authorCysneiros, Roberta M.
dc.contributor.authorTerra, Vera C.
dc.contributor.authorArida, Ricardo M. [UNIFESP]
dc.date.accessioned2016-01-24T14:06:08Z-
dc.date.available2016-01-24T14:06:08Z-
dc.date.issued2011-02-01
dc.identifierhttp://dx.doi.org/10.1016/j.mehy.2010.10.012
dc.identifier.citationMedical Hypotheses. Edinburgh: Churchill Livingstone, v. 76, n. 2, p. 251-253, 2011.
dc.identifier.issn0306-9877
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33416-
dc.description.abstractPeople with schizophrenia show a two to threefold increased risk to die prematurely than those without schizophrenia. Patients' life style, suicide, premature development of cardiovascular disease, high prevalence of metabolic syndrome and sudden cardiac death are well-known causes of the excess mortality. the exact pathophysiological cause of sudden death in schizophrenia is unknown, but it is likely that cardiac arrhythmia and respiratory abnormalities play potential role. Some antipsychotics may be associated with cardiovascular adverse events (e.g., QT interval prolongation) and lesions in specific brain regions, such as cerebella may be associated with respiratory abnormalities, suggesting that metabolic and brain dysfunction could lead to sudden cardiac death in patients with schizophrenia. However, exact knowledge regarding the association of these findings and schizophrenia is lacking. As subclinical hyperthyroidism has been linked with increased risk of cardiovascular disease and cerebella progressive atrophy has been observed in patients with schizophrenia, we propose in this paper that subclinical thyroid dysfunction and cerebella volume loss could be considered as new risk factor for sudden cardiac death in schizophrenia. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipINCT/MCT
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent251-253
dc.language.isoeng
dc.publisherChurchill Livingstone
dc.relation.ispartofMedical Hypotheses
dc.rightsAcesso restrito
dc.titleThyroid gland and cerebella lesions: New risk factors for sudden cardiac death in schizophrenia?en
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Presbiteriana Mackenzie
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Disciplina Neurol Expt, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv Mogi das Cruzes, Fac Med, São Paulo, Brazil
dc.description.affiliationUniv Presbiteriana Mackenzie, Ctr Ciencias Biol & Saude, Programa Posgrad Disturbios Desenvolvimento, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Dept Neurociencias & Ciencias Comportamento, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Fisiol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Disciplina Neurol Expt, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Fisiol, BR-04023900 São Paulo, Brazil
dc.identifier.doi10.1016/j.mehy.2010.10.012
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000287677400031
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