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|Title:||Phase I Safety and Immunogenicity Trial of Plasmodium vivax CS Derived Long Synthetic Peptides Adjuvanted with Montanide ISA 720 or Montanide ISA 51|
Lucia Fernandez, Olga
Palacios, Ricardo [UNIFESP]
Malaria Vaccine & Drug Dev Ctr
Ctr Med Imbanaco
Fdn Clin Valle del Lili
Universidade Federal de São Paulo (UNIFESP)
Family Hlth Int
|Publisher:||Amer Soc Trop Med & Hygiene|
|Citation:||American Journal of Tropical Medicine and Hygiene. Mclean: Amer Soc Trop Med & Hygiene, v. 84, n. 2, p. 12-20, 2011.|
|Abstract:||We assessed the safety, tolerability, and immunogenicity of a mixture of three synthetic peptides derived from the Plasmodium vivax circumsporozoite protein formulated in Montanide ISA 720 or Montanide ISA 51. Forty healthy malaria-naive volunteers were allocated to five experimental groups (A-E): four groups (A-D) were immunized intramuscularly with 50 and 100 mu g/dose injections of a mixture of N, R, and C peptides formulated in the two different adjuvants at 0, 2, and 4 months and one group was administered placebo. Vaccines were immunogenic, safe, well tolerated, and no serious adverse events related to the vaccine occurred. Seroconversion occurred in >90% of the vaccines and antibodies recognized the sporozoite protein on immunofluorescent antibody test. Vaccines in Montanide ISA 51 showed a higher sporozoite protein recognition and interferon production. Results encourage further testing of the vaccine protective efficacy.|
|Appears in Collections:||Em verificação - Geral|
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