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|Title:||Consistent Safety and Infectivity in Sporozoite Challenge Model of Plasmodium vivax in Malaria-Naive Human Volunteers|
Echavarria, Juan Fernando
Palacios, Ricardo [UNIFESP]
Velez, Juan Diego
Epstein, Judith E.
Richie, Thomas L.
Malaria Vaccine & Drug Dev Ctr
Universidade Federal de São Paulo (UNIFESP)
Fdn Clin Valle del Lili
|Publisher:||Amer Soc Trop Med & Hygiene|
|Citation:||American Journal of Tropical Medicine and Hygiene. Mclean: Amer Soc Trop Med & Hygiene, v. 84, n. 2, p. 4-11, 2011.|
|Abstract:||A safe and reproducible Plasmodium vivax infectious challenge method is required to evaluate the efficacy of malaria vaccine candidates. Seventeen healthy Duffy (+) and five Duffy (-) subjects were randomly allocated into three (A-C) groups and were exposed to the bites of 2-4 Anopheles albimanus mosquitoes infected with Plasmodium vivax derived from three donors. Duffy (-) subjects were included as controls for each group. Clinical manifestations of malaria and parasitemia were monitored beginning 7 days post-challenge. All Duffy (+) volunteers developed patent malaria infection within 16 days after challenge. Prepatent period determined by thick smear, was longer for Group A (median 14.5 d) than for Groups B and C (median 10 d/each). Infected volunteers recovered rapidly after treatment with no serious adverse events. the bite of as low as two P vivax-infected mosquitoes provides safe and reliable infections in malaria-naive volunteers, suitable for assessing antimalarial and vaccine efficacy trials.|
|Appears in Collections:||Em verificação - Geral|
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