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Title: White adipose tissue re-growth after partial lipectomy in high fat diet induced obese Wistar rats
Authors: Bueno, Allain Amador
Habitante, Carlos Alexandre
Oyama, Lila Missae [UNIFESP]
Estadella, Debora [UNIFESP]
Ribeiro, Eliane Beraldi [UNIFESP]
Nascimento, Claudia Maria da Penha Oller do [UNIFESP]
London Metropolitan Univ
Univ Fed de Mato Grosso
Universidade Federal de São Paulo (UNIFESP)
Keywords: Partial lipectomy
High fat diet
Adipose tissue
Triacylglycerol deposition
Issue Date: 1-Jan-2011
Publisher: Springer
Citation: Journal of Physiological Sciences. Tokyo: Springer Tokyo, v. 61, n. 1, p. 55-63, 2011.
Abstract: The effects of partial removal of epididymal (EPI) and retroperitoneal (RET) adipose tissues (partial lipectomy) on the triacylglycerol deposition of high fat diet induced obese rats were analyzed, aiming to challenge the hypothesized body fat regulatory system. Male 28-day-old wistar rats received a diet enriched with peanuts, milk chocolate and sweet biscuits during the experimental period. At the 90th day of life, rats were submitted to either lipectomy (L) or sham surgery. After 7 or 30 days, RET, EPI, liver, brown adipose tissue (BAT), blood and carcass were obtained and analyzed. Seven days following surgery, liver lipogenesis rate and EPI relative weight were increased in L. After 30 days, L, RET and EPI presented increased lipogenesis, lipolysis and percentage of small area adipocytes. L rats also presented increased liver malic enzyme activity, BAT lipogenesis, and triacylglycerol and corticosterone serum levels. the partial removal of visceral fat pads affected the metabolism of high fat diet obese rats, which leads to excised tissue regrowth and possibly compensatory growth of non-excised depots at a later time.
ISSN: 1880-6546
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