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Title: Olfactory Heterogeneity in LRRK2 Related Parkinsonism
Authors: Silveira-Moriyama, Laura
Munhoz, Renato Pupi
Carvalho, Margarete de J.
Raskin, Salmo
Rogaeva, Ekaterina
Aguiar, Patricia de C.
Bressan, Rodrigo A. [UNIFESP]
Felicio, Andre C. [UNIFESP]
Barsottini, Orlando G. P. [UNIFESP]
Andrade, Luiz Augusto Franco de [UNIFESP]
Chien, Hsin F.
Bonifati, Vincenzo
Barbosa, Egberto R.
Teive, Helio A.
Lees, Andrew J.
Univ Fed Parana
Universidade de São Paulo (USP)
Univ Toronto
Hosp Israelita Albert Einstein
Universidade Federal de São Paulo (UNIFESP)
Erasmus MC
Keywords: olfaction
Issue Date: 15-Dec-2010
Publisher: Wiley-Blackwell
Citation: Movement Disorders. Hoboken: Wiley-liss, v. 25, n. 16, p. 2879-2883, 2010.
Abstract: LRRK2 mutations can cause familial and sporadic Parkinson's disease (PD) with Lewy-body pathology at post-mortem. Studies of olfaction in LRRK2 are sparse and incongruent. We applied a previously validated translation of the 16 item smell identification test from Sniffin' Sticks (SS-16) to 14 parkinsonian carriers of heterozygous G2019S LRRK2 mutation and compared with 106 PD patients and 118 healthy controls. the mean SS-16 score in LRRK2 was higher than in PD (p < 0.001, 95% CI for beta = -4.7 to -1.7) and lower than in controls (p = 0.007, 95% CI for beta = +0.6 to +3.6). in the LRRK2 group, subjects with low scores had significantly more dyskinesia. They also had younger age of onset, longer disease duration, and reported less frequently a family history of PD, but none of these other differences reached significance. Odor identification is diminished in LRRK2 parkinsonism but not to the same extent as in idiopathic PD. (C) 2010 Movement Disorder Society
ISSN: 0885-3185
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