Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/33149
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dc.contributor.authorMiyamoto, Maristela
dc.contributor.authorPessoa, Silvana D.
dc.contributor.authorOno, Erika
dc.contributor.authorMachado, Daisy M.
dc.contributor.authorSalomão, Reinaldo [UNIFESP]
dc.contributor.authorSucci, Regina C. de M.
dc.contributor.authorPahwa, Savita
dc.contributor.authorMoraes-Pinto, Maria Isabel de [UNIFESP]
dc.date.accessioned2016-01-24T14:05:47Z
dc.date.available2016-01-24T14:05:47Z
dc.date.issued2010-12-01
dc.identifierhttp://dx.doi.org/10.1093/tropej/fmq024
dc.identifier.citationJournal of Tropical Pediatrics. Oxford: Oxford Univ Press, v. 56, n. 6, p. 427-432, 2010.
dc.identifier.issn0142-6338
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33149
dc.description.abstractLymphocyte subsets, activation markers and apoptosis were assessed in 20 HIV-exposed noninfected (ENI) children born to HIV-infected women who were or not exposed to antiretroviral (ARV) drugs during pregnancy and early infancy. ENI children and adolescents were aged 6-18 years and they were compared to 25 age-matched healthy non-HIV-exposed children and adolescents (Control). ENI individuals presented lower CD4(+) T cells/mm(3) than Control group (control: 1120.3 vs. ENI: 876.3; t-test, p=0.030). ENI individuals had higher B-cell apoptosis than Control group (Control: 36.6%, ARV exposed: 82.3%, ARV nonexposed: 68.5%; Kruskal-Wallis, p < 0.05), but no statistical difference was noticed between those exposed and not exposed to ARV. Immune activation in CD4(+) T, CD8(+) T and in B cells was comparable in ENI and in Control children and adolescents. Subtle long-term immune alterations might persist among ENI individuals, but the clinical consequences if any are unknown, and these children require continued monitoring.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipMiami Fogarty
dc.description.sponsorshipMiami Developmental Center for AIDS Research
dc.format.extent427-432
dc.language.isoeng
dc.publisherOxford Univ Press
dc.relation.ispartofJournal of Tropical Pediatrics
dc.rightsAcesso restrito
dc.subjectHuman Immunodeficiency Virusen
dc.subjectapoptosisen
dc.subjectlymphocyte activationen
dc.subjectantiretroviral agentsen
dc.subjectCD4 T cellen
dc.subjectB cellen
dc.titleLow CD4(+) T-Cell Levels and B-Cell Apoptosis in Vertically HIV-exposed Noninfected Children and Adolescentsen
dc.typeArtigo
dc.rights.licensehttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Miami
dc.description.affiliationUniversidade Federal de São Paulo, Res Lab, Div Pediat Infect Dis, Dept Pediat, BR-04039032 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Med, Div Infect Dis, São Paulo, Brazil
dc.description.affiliationUniv Miami, Miller Sch Med, Dept Microbiol & Immunol & Pediat, Miami, FL 33136 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Res Lab, Div Pediat Infect Dis, Dept Pediat, BR-04039032 São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 04/15316-4
dc.description.sponsorshipIDFAPESP: 04/15317-0
dc.description.sponsorshipIDMiami Fogarty: AITRP5D43TW000017
dc.description.sponsorshipIDMiami Developmental Center for AIDS Research: P30AI073961
dc.identifier.doi10.1093/tropej/fmq024
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000284645100010
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