Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/33122
Title: Vitamin D status in a sunny country: Where has the sun gone?
Authors: Unger, Marianna D.
Cuppari, Lilian [UNIFESP]
Titan, Silvia M.
Magalhaes, Maria Claudia T.
Sassaki, Ana L.
Reis, Luciene M. dos
Jorgetti, Vanda
Affonso Moyses, Rosa Maria
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Keywords: 25 Vitamin D
Hypovitaminosis D
Parathyroid hormone
Secondary hyperparathyroidism
Sun radiation
Age
Issue Date: 1-Dec-2010
Publisher: Churchill Livingstone
Citation: Clinical Nutrition. Edinburgh: Churchill Livingstone, v. 29, n. 6, p. 784-788, 2010.
Abstract: Background & aims: Hypovitaminosis D [serum 25 vitamin D < 30 ng/ml] is related to the development of metabolic bone disease and greater risk of chronic illnesses. However, it is frequently under-diagnosed, mainly in countries where UV radiation is abundant. We prospectively determined the prevalence and the predictors of serum 25 vitamin D (s25(OH)D) in a healthy Brazilian population after the winter and after the summer.Methods: 603 (118M and 485F) healthy Brazilian volunteers aged 18-90 years from a universitary hospital were selected after the winter of 2006. From the initial sample, 209 volunteers (31M and 178F) accepted to participate in a second health check after the subsequent summer.Results: After the winter, median s25(OH)D was 21.4 ng/mL and 77.4% of the population presented hypovitaminosis D. s25(OH)D was significantly related to age, BMI, PTH and race. in multivariate linear regression analysis, s25(OH)D was significantly and independently dependent on age, glycemia and skin color. Significant increase in s25(OH)D was verified after summer [10.6 (3.7-19.3 ng/ml); p < 0.001] and this improvement was dependent on age. We also observed a significant decrease in hyperparathyroidism prevalence (20.8% vs. 4.9%; P < 0.0001).Conclusion: in São Paulo, at the end of winter, we observed a high prevalence of hypovitaminosis D and secondary hyperparathyroidism in healthy adults. s25(OH)D was dependent on age and skin color. After summer, we observed a decrease in the prevalence of hypovitaminosis D. This unexpected finding emphasizes the need for a strong recommendation to monitor s25(OH)D, even in a sunny country such as Brazil. (C) 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/33122
ISSN: 0261-5614
Other Identifiers: http://dx.doi.org/10.1016/j.clnu.2010.06.009
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.