Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/33077
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dc.contributor.authorSantos, Leonardo dos [UNIFESP]
dc.contributor.authorSantos, Alexandra A. [UNIFESP]
dc.contributor.authorGoncalves, Giovana A.
dc.contributor.authorKrieger, Jose Eduardo
dc.contributor.authorFerreira Tucci, Paulo Jose [UNIFESP]
dc.date.accessioned2016-01-24T14:05:41Z-
dc.date.available2016-01-24T14:05:41Z-
dc.date.issued2010-11-05
dc.identifierhttp://dx.doi.org/10.1016/j.ijcard.2009.06.008
dc.identifier.citationInternational Journal of Cardiology. Clare: Elsevier B.V., v. 145, n. 1, p. 34-39, 2010.
dc.identifier.issn0167-5273
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33077-
dc.description.abstractBackground: Since the cell therapy benefits for myocardial infarction are mainly related to infarct reduction by regenerating lost myocardium or increasing survival of tissues at risk, we evaluated the effects of bone marrow-derived mononuclear cells (MNC), implanted after the completion of necrosis, on infarct progression and cardiac remodeling.Methods: After 48 h of induction of myocardial infarction (MI), Lewis-inbred rats were injected with 6 x 10(6) cells (MI + MNC) or saline (MI). After six weeks, scar dimension, ventricular morphology and function were analyzed by echocardiography followed by histomorphology of the infarcted and border zones.Results: After therapy, the relative size of the infarct was smaller in MI + MNC (37 +/- 1% of the left ventricle) than in MI (43 +/- 1%). While the MI group exhibited parallel elongation of the infarcted (31.6 +/- 3.8% increase) and reminiscent ventricular portions (33.5 +/- 3.7%), MNC therapy preserved the initial infarct length. Infarcted walls were thicker (979 +/- 31 mm) in the MNC group than in the untreated group (709 +/- 41 mm), also demonstrating an absence of infarct expansion. in the border zones, MNC led to increased capillary densities and capillary/myocyte ratios. the cardiac systolic function remained depressed in MI, but improved by 19 +/- 5% in MI + MNC which reduced the incidence of pulmonary arterial hypertension (37.5% in MI and 6.25% in MI + MNC).Conclusion: MNC therapy prevented the infarct expansion and thinning related to cardiac remodeling and was associated with an improvement of border zone microcirculation: as a result, MNC therapy reduced typical MI dysfunctional repercussions. (C) 2009 Elsevier Ireland Ltd. All rights reserved.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent34-39
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Cardiology
dc.rightsAcesso restrito
dc.subjectStem cellen
dc.subjectCapillary densityen
dc.subjectMyocardial infarctionen
dc.subjectBone marrowen
dc.subjectRatsen
dc.titleBone marrow cell therapy prevents infarct expansion and improves border zone remodeling after coronary occlusion in ratsen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Div Cardiol, BR-04024900 São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Cardioresp Physiol Div, Dept Physiol, BR-04020041 São Paulo, SP, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Inst Heart InCor, BR-05403000 São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Div Cardiol, BR-04024900 São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Cardioresp Physiol Div, Dept Physiol, BR-04020041 São Paulo, SP, Brazil
dc.identifier.doi10.1016/j.ijcard.2009.06.008
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000283727000019
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