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Title: Effect of type 2 diabetes on plasma kallikrein activity after physical exercise and its relationship to post-exercise hypotension
Authors: Motta, D. F.
Lima, L. C. J.
Arsa, G.
Russo, P. S.
Sales, M. M.
Moreira, S. R.
Morais, P. K.
Almeida, W. S.
Araujo, R. C. [UNIFESP]
Moraes, M. R. [UNIFESP]
Pesquero, J. L.
Simoes, H. G.
Campbell, C. S. G.
Univ Catolica Brasilia
Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de São Paulo (UNIFESP)
Fed Univ Vale do Sao Francisco
Keywords: Post-exercise hypotension
Type 2 diabetes
Blood pressure
Kallikrein activity
lactate threshold
Issue Date: 1-Nov-2010
Publisher: Masson Editeur
Citation: Diabetes & Metabolism. Moulineaux Cedex 9: Masson Editeur, v. 36, n. 5, p. 363-368, 2010.
Abstract: Aim.-The present study was undertaken to determine the effects of type 2 diabetes (T2D) on plasma kallikrein activity (PKA) and postexercise hypotension (PEH).Methods. - Ten T2D patients (age: 53.6 +/- 1.3 years; body mass index: 30.6 +/- 1.0 kg/m(2); resting blood glucose: 157.8 +/- 40.2 mg dL(-1)) and 10 non-diabetic (ND) volunteers (age: 47.5 +/- 1.0 years; body mass index: 28.3 +/- 0.9 kg/m(2); resting blood glucose: 91.2 +/- 10.5 mg dL(-1)) underwent two experimental sessions, consisting of 20 mm of rest plus 20 min of exercise (EXE) at an intensity corresponding to 90% of their lactate threshold (90LT) and a non-exercise control (CON) session. Blood pressure (BP; Microlife BP 3ACI-1 monitor) and PKA were measured during rest and every 15 min for 135 min of the postexercise recovery period (RP).Results. - During the RP, the ND individuals presented with PEH at 30, 45 and 120 min (P < 0.05) while, in the T2D patients, PEH was not observed at any time. PKA increased at 15 min postexercise in the ND (P < 0.05), but not in the T2D patients.Conclusion. - T2D individuals have a lower PKA response to exercise, which probably suppresses its hypotensive effect, thus reinforcing the possible role of PKA on PEH. (C) 2010 Elsevier Masson SAS. All rights reserved.
ISSN: 1262-3636
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