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Title: Social play impairment following status epilepticus during early development
Authors: Santos Castelhano, Adelisandra Silva
Scorza, Fulvio Alexandre [UNIFESP]
Triguero Veloz Teixeira, Maria Cristina
Arida, Ricardo Mario [UNIFESP]
Cavalheiro, Esper Abrao [UNIFESP]
Cysneiros, Roberta Monterazzo
Univ Presbiteriana Mackenzie
Universidade Federal de São Paulo (UNIFESP)
Keywords: Gender
Social interaction
Status epilepticus
Issue Date: 1-Oct-2010
Publisher: Springer
Citation: Journal of Neural Transmission. Wien: Springer Wien, v. 117, n. 10, p. 1155-1160, 2010.
Abstract: Neonatal status epilepticus (SE) disrupts prefrontal cortex and thalamus, brain regions related to social play. Juvenile play was evaluated using the intruder-resident paradigm following SE in 9-day-old Wistar pups of both genders. Quite interestingly, we demonstrated for the first time that neonatal SE produces social impairment in male rats, reduces locomotor activity in both genders and enhances self-grooming in female. Additional studies are necessary to clarify if these effects can impair social behavior across the life span.
ISSN: 0300-9564
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Appears in Collections:Em verificação - Geral

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