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Title: Sclerochorioretinal Abnormalities in Hypercholesterolemic Rabbits Treated With Rosiglitazone
Authors: Almeida Torres, Rogil Jose de [UNIFESP]
Muccioli, Cristina [UNIFESP]
Maia, Mauricio [UNIFESP]
Noronha, Lucia
Luchini, Andrea
Alessi, Alexandre
Olandoski, Marcia
Farah, Michel Eid [UNIFESP]
Precoma, Dalton Bertolin
Universidade Federal de São Paulo (UNIFESP)
Pontificia Univ Catolica Parana
Ctr Oftalmol Curitiba
Issue Date: 1-Sep-2010
Publisher: Slack Inc
Citation: Ophthalmic Surgery Lasers & Imaging. Thorofare: Slack Inc, v. 41, n. 5, p. 562-571, 2010.
Abstract: BACKGROUND and OBJECTIVE: To evaluate early retinal, choroidal, and scleral abnormalities induced by a hypercholesterolemic diet and the prevention of these abnormalities after oral administration of rosiglitazone in rabbits.MATERIALS and METHODS: Fifty-four New Zealand rabbits were divided into four study groups: control group, normal diet; group 1, hypercholesterolemic diet; group 2, hypercholesterolemic diet associated with daily administration of 3 mg of rosiglitazone from day 14 after beginning the diet; and group 3, hypercholesterolemic diet associated with daily administration of 3 mg of rosiglitazone since the beginning of the experiment. Sclera and choroid underwent histologic and histomorphometric analyses. Retina underwent immunohistochemical analysis with anti-calretinin and anti-glial fibrillary acidic protein (GFAP) antibodies.RESULTS: No abnormalities were observed in the control group. Group 1 had significant increases in scleral and choroidal thicknesses compared with the control group (P < .01) and group 3 (P < .05). Group 1 presented significant increases in immunoreactivity (P < .001) to the anti-calretinin antibody compared with the other groups. Groups 2 and 3 had significant (P < .002) increases in calretinin immunoreactivity compared with the control group. GFAP was negative in all groups.CONCLUSION: the hypercholesterolemic diet induced early retinal, choroidal, and scleral abnormalities. Rosiglitazone preserved the structural anatomy.
ISSN: 1542-8877
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