Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/32886
Title: Seizures during pregnancy modify the development of hippocampal interneurons of the offspring
Authors: Vale, Tiago Gurgel do [UNIFESP]
Silva, Alexandre Valotta da [UNIFESP]
Lima, Daiana Correia [UNIFESP]
Lima, Eliangela de [UNIFESP]
Torres, Laila Brito [UNIFESP]
Cossa, Ana Carolina [UNIFESP]
Oliveira, Elaine Menezes de [UNIFESP]
Cabral, Francisco Romero
Cavalheiro, Esper Abrao [UNIFESP]
Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
Amado, Debora [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Ctr Nacl Primatas
Hosp Albert Einstein
Issue Date: 1-Sep-2010
Publisher: Elsevier B.V.
Citation: Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 19, n. 1, p. 20-25, 2010.
Abstract: We investigated the effect of epileptic seizures during pregnancy on hippocampal expression of calcium-binding proteins in the offspring. Female Wistar rats were submitted to the pilocarpine model and mated during the chronic period. Seizure frequency was monitored over the entire pregnancy. Pups were perfused at postnatal days 6 and 13. and the brains processed for Nissl staining and immunohistochemistry for NeuN, calbindin, calretinin, and parvalbumin. Number of stained cells in the hippocampus was estimated through stereological methods. Our results showed a decrease in epileptic seizure frequency during pregnancy. No differences were observed in NeuN-positive. CR-positive cells, and Nissl-stained hippocampal neurons between the groups. However, there was a significant decrease in calbindin-positive cells (P=0.005) and a significant increase in parvalbumin-positive cells (P=0.02) in the experimental group when compared with the control group. These results suggest that seizures during pregnancy affect the development of specific hippocampal interneurons of the offspring. (C) 2010 Elsevier Inc. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/32886
ISSN: 1525-5050
Other Identifiers: http://dx.doi.org/10.1016/j.yebeh.2010.06.032
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.