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|Title:||Candidemia Surveillance in Brazil: Evidence for a Geographical Boundary Defining an Area Exhibiting an Abatement of Infections by Candida albicans Group 2 Strains|
|Authors:||Matta, Daniel Archimedes da [UNIFESP]|
Melo, Analy S. [UNIFESP]
Colombo, Arnaldo L. [UNIFESP]
Frade, Joao P.
Nucci, Marcio [UNIFESP]
Lott, Timothy J.
Ctr Dis Control & Prevent
Universidade Federal de São Paulo (UNIFESP)
|Publisher:||Amer Soc Microbiology|
|Citation:||Journal of Clinical Microbiology. Washington: Amer Soc Microbiology, v. 48, n. 9, p. 3062-3067, 2010.|
|Abstract:||Prospective population surveillance has been conducted for candidemia in Brazil (A. L. Colombo, M. Nucci, B. J. Park, et al., J. Clin. Microbiol. 44:2816-2823, 2006). in the present study, a total of 63 isolates from 61 patients, representing 11 medical centers from nine geographic regions, were characterized by multilocus sequence typing (MLST). A total of 48 unique profiles or diploid sequence types (DSTs) were observed, with nine new sequence types (STs) and 32 new DSTs. There were no apparent correlations between center/region and DST patterns. Subtypes were compared to those in a known characterized reference set, including a large database of strains obtained worldwide. Significantly, only one C. albicans group 2 isolate was found in our collection, although isolates from this particular group are commonly found worldwide. These data, combined with information from other previously reported studies, establish a statistically significant diminishment of group 2 strains in Central and South America, including Mexico and portions of the Southwestern United States.|
|Appears in Collections:||Em verificação - Geral|
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