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Title: Hypotensive Effect of Juxtascleral Administration of Anecortave Acetate in Different Types of Glaucoma
Authors: Prata, Tiago Santos [UNIFESP]
Tavares, Ivan Maynart [UNIFESP]
Mello, Paulo Augusto de Arruda [UNIFESP]
Tamura, Caroline [UNIFESP
Lima, Veronica Castro
Belfort, Rubens [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Keywords: intraocular pressure
anecortave acetate
Issue Date: 1-Sep-2010
Publisher: Lippincott Williams & Wilkins
Citation: Journal of Glaucoma. Philadelphia: Lippincott Williams & Wilkins, v. 19, n. 7, p. 488-492, 2010.
Abstract: Purpose: To evaluate the intraocular pressure (IOP)-lowering effect of anecortave acetate, delivered by anterior juxtascleral depot injection, in eyes with various forms of glaucoma.Methods: A prospective, interventional case series was carried out. Twenty-eight uncontrolled glaucoma patients received a single injection of anecortave acetate (24 to 30 mg) in 1 selected eye under topical anesthesia. Postinjection assessments were scheduled at week 1 and months 1, 2, and 3.Results: Mean +/- SD age of patients was 58.2 +/- 18.6 years. Twelve patients had open-angle glaucoma and 16 had angle-closure glaucoma. Uveitic/steroid-induced glaucoma was the most frequent diagnosis (11 patients, 39.2%). Mean baseline IOP was 30.7 +/- 9.3mm Hg. Mean IOP at week 1 and months 1, 2, and 3 were 21.3 +/- 6.1, 19.8 +/- 6.3, 20.9 +/- 7.3, and 21.7 +/- 6.8mm Hg, respectively. Significant mean IOP reductions were observed at week 1 and months 1, 2, and 3 (29.3%, 33.8%, 30.1%, and 27.2%, respectively; P < 0.001).Conclusion: A single administration of anecortave acetate by anterior juxtascleral depot injection seems to result in a significant IOP reduction (compared with baseline) for at least 3 months in eyes with different types of glaucoma. No injection-related or drug-related serious adverse events were observed. Additional studies are required to better determine the efficacy, safety, and mechanism of action of this alternative treatment.
ISSN: 1057-0829
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