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Title: Bone Deposition, Bone Resorption, and Osteosarcoma
Authors: Toledo, Silvia Regina Caminada de [UNIFESP]
Oliveira, Indhira Dias [UNIFESP]
Okamoto, Oswaldo Keith [UNIFESP]
Zago, Marco Antonio
Alves, Maria Teresa de Seixas [UNIFESP]
Garcia Filho, Reynaldo Jesus [UNIFESP]
Macedo, Carla Renata Donato Pacheco [UNIFESP]
Petrilli, Antonio Sergio [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Keywords: osteosarcoma
bone remodeling
Issue Date: 1-Sep-2010
Publisher: Wiley-Blackwell
Citation: Journal of Orthopaedic Research. Hoboken: John Wiley & Sons Inc, v. 28, n. 9, p. 1142-1148, 2010.
Abstract: Bone deposition and bone resorption are ongoing dynamic processes, constituting bone remodeling. Some bone tumors, such as osteosarcoma (OS), stimulate focal bone deposition. OS is the most common primary bone tumor in children and young adults. A complex network of genes regulates bone remodeling and alterations in its expression levels can influence the genesis and progression of bone diseases, including OS. We hypothesized that the expression profiles of bone remodeling regulator genes would be correlated with OS biology and clinical features. We used real-time PCR to evaluate the mRNA levels of the tartrate-resistant acid phosphatase (ACP5), colony stimulating factor-1 (CSF1R), bone morphogenetic protein 7 (BMP7), collagen, type XI, alpha 2 (COL11A2), and protein tyrosine phosphatases zeta 1 (PTPRZ1) genes, in 30 OS tumor samples and correlated with clinical and histological data. All genes analyzed, except CSF1R, were differentially expressed when compared with normal bone expression profiles. in our results, OS patients with high levels of COL11A2 mRNA showed worse overall (p = 0.041) and event free survival (p = 0.037). Also, a trend for better overall survival was observed in patients with samples showing higher expression of BMP7 (p =0.067). COL11A2 overexpression and BMP7 underexpression could collaborate to OS tumor growth, through its central role in bone remodeling process. (C) 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:1142-1148, 2010
ISSN: 0736-0266
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