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|Title:||Repeated stress reduces mucociliary clearance in animals with chronic allergic airway inflammation|
Toledo, Alessandra C.
Reis, Fabiana G.
Marques, Ricardo H.
Prado, Carla M. [UNIFESP]
Martins, Milton A.
Leick-Maldonado, Edna A.
Tiberio, Iolanda F. L. C.
Universidade de São Paulo (USP)
Lusiada Fac Med Sci
Universidade Federal de São Paulo (UNIFESP)
Experimental model of chronic airway
|Citation:||Respiratory Physiology & Neurobiology. Amsterdam: Elsevier B.V., v. 173, n. 1, p. 79-85, 2010.|
|Abstract:||We evaluated if repeated stress modulates mucociliary clearance and inflammatory responses in airways of guinea pigs (GP) with chronic inflammation. the GP received seven exposures of ovalbumin or saline 0.9%. After 4th inhalation, animals were submitted to repeated forced swim stressor protocol (5x/week/2 weeks). After 7th inhalation, GP were anesthetized. We measured transepithelial potential difference, ciliary beat frequency, mucociliary transport, contact angle, cough transportability and serum cortisol levels. Lungs and adrenals were removed, weighed and analyzed by morphometry. Ovalbumin-exposed animals submitted to repeated stress had a reduction in mucociliary transport, and an increase on serum cortisol, adrenals weight, mucus wettability and adhesivity, positive acid mucus area and IL-4 positive cells in airway compared to non-stressed ovalbumin-exposed animals (p < 0.05). There were no effects on eosinophilic recruitment and IL-13 positive cells. Repeated stress reduces mucociliary clearance due to mucus theological-property alterations, increasing acid mucus and its wettability and adhesivity. These effects seem to be associated with IL-4 activation. (C) 2010 Elsevier B.V. All rights reserved.|
|Appears in Collections:||Em verificação - Geral|
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